Front Cover Story (See: Junzheng Zhang, Tong Dou, Yun Shen, Wenrui Wang, Luokai Wang, Xuanhao Wu, Meng Zhang, Dongsheng Wang, Pingfeng Yu, 2024, 18(11): 136)
Current microbial control strategies are struggling to keep pace with escalating microbial problems due to the presence of biofilms. Nanozymes, with intrinsic biocatalytic activity and broad antibacterial spectra, hold promise for controlling resilient biofilms. This review summarizes the milestones of nanozyme studies and their applications as antibiofilm agents. The mechanisms behind antibacterial, quorum quenching, and depolymerizing properties of nanozymes with different enzyme activities are discussed. Additionally, the challenges of nanozyme applications in real environments are investigated, along with proposed strategies to overcome these challenges. Overall, this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.
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