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2022年, 第16卷 第6期
Inspired by the integration process, aluminum hydrogel (alum)-stabilized oil-in-water emulsions (ASEs) was assembled in a modular way. The oil phase was screened thoroughly for the enhanced anti-oxidative capability and long-term-storage stability. Subsequently, alum was adsorbed and packed on the squalene/water interphase, forming the particulate emulsion droplet. With the hydrophobic and electrostatic interactions, the droplet increased the antigen loading efficiency and induced potent antigen-specific antibody secretion and T-cell-mediated immune responses. Furthermore, the acceptable biosafety profile was also elicited. The featured paper also studied the the underlying mechanisms of droplet stability and the boosted immunogenicity, which may offer an alternative strategy for safe, stable, and effective emulsion adjuvants. (see Lili Yuan, Xiao-Dong Gao, Yufei Xia, pp. 973–984)[展开] ...
ISSN 2095-0179 (Print)
ISSN 2095-0187 (Online)
CN 11-5981/TQ
Postal Subscription Code 80-969 Formerly Known as Frontiers of Chemical Science and Engineering in China 2018 Impact Factor: 2.809