Nov 2017, Volume 8 Issue 10

Cover illustration

  • The enzyme that degrades mitochondrial RNAs in mammalian cells had eluded discovery for decades. It had long been assumed that the degradation happens in mitochondrial matrix where transcription and translation occur. Liu et al. provide compelling evidence that mammalian mitochondrial RNA degradation happens in mitochondrial intermembrane space (IMS) and RNASET2 is the ribonuclease for the process. RNASET2 activity also has an effect on mitochondrial transcription in the matr [Detail] ...

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