Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia

Mingya Liu; Feifei Qi; Jue Wang; Fengdi Li; Qi Lv; Ran Deng; Xujian Liang; Shasha Zhou; Pin Yu; Yanfeng Xu; Yaqing Zhang; Yiwei Yan; Ming Liu; Shuyue Li; Guocui Mou; Linlin Bao

doi:10.1093/procel/pwae045

Protein Cell ›› 2025, Vol. 16 ›› Issue (2) : 148 -155. DOI: 10.1093/procel/pwae045

LETTER

Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia

Mingya Liu ¹
, Feifei Qi ¹^,²
, Jue Wang ¹^,²
, Fengdi Li ¹^,²
, Qi Lv ¹^,²
, Ran Deng ¹^,²
, Xujian Liang ¹^,²
, Shasha Zhou ¹
, Pin Yu ¹^,²
, Yanfeng Xu ¹^,²
, Yaqing Zhang ¹
, Yiwei Yan ¹
, Ming Liu ¹
, Shuyue Li ¹
, Guocui Mou ¹
, Linlin Bao ¹^,²^,³^,^†

Author information +

History +

PDF (21106KB)

Cite this article

Download citation ▾

Mingya Liu, Feifei Qi, Jue Wang, Fengdi Li, Qi Lv, Ran Deng, Xujian Liang, Shasha Zhou, Pin Yu, Yanfeng Xu, Yaqing Zhang, Yiwei Yan, Ming Liu, Shuyue Li, Guocui Mou, Linlin Bao. Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia. Protein Cell, 2025, 16(2): 148-155 DOI:10.1093/procel/pwae045

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Abers MS, Delmonte OM, Ricotta EE et al. NIAID COVID-19 Consortium. An immune-based biomarker signature is associated with mortality in COVID-19 patients. JCI Insight 2021;6:e144455.

[2]	Bao L, Deng W, Huang B et al. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature 2020;583:830–833.

[3]	Horita N, Fukumoto T. Global case fatality rate from COVID-19 has decreased by 96.8% during 2.5 years of the pandemic. J Med Virol 2023;95:e28231.

[4]	Huang Z, Li H, Liu S et al. Identification of neutrophil-related factor LcN2 for predicting severity of patients with influenza a virus and SARS-CoV-2 infection. Front Microbiol 2022;13:854172.

[5]	Lai D, Zhu K, Li S et al. SARS-CoV-2 N protein triggers acute lung injury via modulating macrophage activation and infiltration in in vitro and in vivo. J Inflamm Res 2023;16:1867–1877.

[6]	Oberoi R, Bogalle EP, Matthes LA et al. Lipocalin 2 mediates pro-atherosclerotic processes and is elevated in patients with coronary artery disease. PLoS One 2015;10:e0137924.

[7]	Reglero-Real N, Colom B, Bodkin JV et al. Endothelial cell junctional adhesion molecules: role and regulation of expression in inflammation. Arterioscler Thromb Vasc Biol 2016;36:2048–2057.

[8]	Saito A, Irie T, Suzuki R et al. Genotype to Phenotype Japan (G2P-Japan) Consortium. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature 2022;602:300–306.

[9]	Shen H, Wang Z, Huang A et al. Lipocalin 2 is a regulator during macrophage polarization induced by soluble worm antigens. Front Cell Infect Microbiol 2021;11:747135.

[10]	Sun SH, Chen Q, Gu HJ et al. A mouse model of SARS-CoV-2 infection and pathogenesis. Cell Host Microbe 2020;28:124–133.e4.

[11]	Sun W, Wu W, Jiang N et al. Highly pathogenic PRRSV-infected alveolar macrophages impair the function of pulmonary microvascular endothelial cells. Viruses 2022;14:452.

[12]	Wu ML, Liu FL, Sun J et al. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury. Signal Transduct Target Ther 2021;6:428.