Nov 2017, Volume 8 Issue 11

Cover illustration

  • A new three-dimensional organoid culture system from iPSCs in vitro has been reported to recapitulate normal cortical development and neural developmental diseases. Organoids derived from this culture system generate ventricle-like cavities surrounded by progenitor cells (green), while new-born neurons (red) locate superficially. In these organoids, ventricular zone (VZ), subventricular zone (SVZ), lower and upper cortical plate (CP) display a well-aligned layer stru [Detail] ...

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