Mar 2017, Volume 8 Issue 3

Cover illustration

  • Metastasis is a major death causing factor in breast cancer, lacking effective treatments. Th2 and M2macrophages have been associated with metastasis in breast cancer models and are considered as potential targets for immunotherapy. Here for the first time, we characterized the expression and function of IL-25 in a spontaneous breast cancer model and found its blockade re-shaped tumor microenvironments and reduced tumor metastasis to the lung. Our study thus identified IL-25 [Detail] ...

  • Select all