A new thinprep cytologic test of cervical cells and its application

Abstract

In order to improve the quality of routine cervical smears, we investigated the new Thinprep cytologic test (TCT) for cervical cells. In this study, 100 women who were enrolled were randomly divided into two groups. In one group, the TCT for cervical cells was applied (TCT group), and in the other group routine cervical smear was used. In addition, the cells in the TCT group were screened by double sifters, and centrifuged using a separation medium so as to eliminate mucus, inflammatory cells and blood cells. According to the cell distribution and the thickness of the smear, the results were assigned to three groups, including satisfactory smears, less satisfactory smears and unsatisfactory smears. The TCT had a higher satisfactory rate (98%) compared to the routine cervical smear (32%) (P<0.01), indicating the TCT was superior to the routine cervical smear. It is concluded that the TCT is more acceptable. Meanwhile, in comparison to the routine cervical smear, the TCT for cervical cells has 5 advantages which can greatly increase the cytological accuracy.

Key words： thinprep cytologic test; cervical cells; Papanicolaou smear

References

1 LiX M.Mental nursing of temple neck cancer patients operated. Shi Yong Yi Ji Za Zhi, 2006, 13(2): 279-280 (in Chinese)

2 KuhnL,DennyL,PollackA,LorinczA,RichartR M,WrightT C. Human papillomavirus DNA testing for cervical cancer screening in low-resource settings. J Natl Cancer lnst, 2000, 92(10): 818-825

3 MunozN. Human papillomavirus and cancer: the epidemiological evidence. J Clin Virol, 2000, 19(1,2): 1-5

4 PisaniP,BrayF,ParkinD M. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer, 2002, 97(1): 72-81

5 ZhangW Y,XueY Z,ChenM,HanL,LuoM. Prevalence of high-risk human papillomavirus infection in different cervical lesion among organized health-examination women in Shanghai, China. Chin Med J, 2008, 121(16): 1578-1582

6 BrayF,SankilaR,FerlayJ,ParkinD. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer, 2002, 38(1): 99-166

7 XuL Z. Retrospect and prospect of clinical oncocytological research. Aizheng, 2004, 23(12): 1717-1720 (in Chinese)

8 PapanicolaouG N,TrautH F. The diagnostic value of vaginal smears in carcinoma of the uterus. 1941. Arch Pathol Lab Med, 1997, 121(3): 211-224

9 SolomonD,DaveyD,KurmanR,MoriartyA,O’ConnorD,PreyM,RaabS,ShermanM,WilburD,WrightT Jr,YoungN; Forum Group Members; Bethesda 2001 Workshop. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA, 2002, 287(16): 2114-2119

10 LangJ H. The chance to greed the global challenge to the cervical cancer prevention. Zhong Hua Fu Ke Za Zhi, 2002, 37(1): 1 (in Chinese)

11 LiuX Y,FengF Y,ZhaoS H. American Cancer Society guidelines for the early detection of cancer. Zhongguo Yikan, 2004, 39(7): 49-50 (in Chinese)

12 ShiP,LiJ X,ZhangY Z. Comparing the Conventional Papanicolaou Smear Test with liquid-based Cytology. Shanxi Yiyao Zazhi, 2004, 33(5): 423-425 (in Chinese)

13 BrayF,LoosA H,McCarronP,WeiderpassE,ArbynM,M旿llerH,HakamaM,ParkinD M. Trends in cervical squamous cell carcinoma incidence in 13 European countries: changing risk and the effects of screening. Cancer Epidemiol Biomarkers Prev, 2005, 14(3): 677-686

14 DeMayR M. Common problems in papanieolaou smear interpretatin. Arch Patho1 Lab Med, 1997, 12l(3): 229-238

15 FrableW J. Does a zero error standard exist for the papanicolaou smear? A pathologist’s perspective. Arch Pathol Lab Med, 1997, 121(3): 301-310

16 HutchinsonM L,IsensteinL M,GoodmanA,HurleyA A,DouglassK L,MuiK K,PattenF W,ZahniserD J. Homogeneous sampling accounts for the increased diagnostic accuracy using the Thinprep Processor. Am J Clin Pathol, 1994, 101(2): 215-219

17 SunG T. The advancement of the automation and normalization of the cervical cytological examination. Yixue Linchuang Yanjiu, 2003, 20(10): 782-785 (in Chinese)

18 RoncoG,Giorgi-RossiP,CarozziF,Dalla PalmaP,Del MistroA,De MarcoL,De LilloM,NaldoniC,PierottiP,RizzoloR,SegnanN,SchincagliaP,ZorziM,ConfortiniM,CuzickJ; New Technologies for Cervical Cancer screening Working Group. Human papillomavirus testing and liquid-based cytology in primary screening of women younger than 35 years: results at recruitment for a randomised controlled trial. Lancet Oncol, 2006, 7(7): 547-555