Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Received date: 26 Sep 2011
Accepted date: 02 Nov 2011
Published date: 05 Mar 2012
Copyright
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
Chong Liu , Dingfeng Su . Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases[J]. Frontiers of Medicine, 2012 , 6(1) : 35 -40 . DOI: 10.1007/s11684-012-0171-0
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