Frontiers of Chemical Science and Engineering >

2010 , Vol. 4 >Issue 1: 70 - 74

DOI: https://doi.org/10.1007/s11705-009-0293-3

Research articles

Effects of ionic impurities on crystallization of cobalamin

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  • 1.School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China; 2.School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China；School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

Published date: 05 Mar 2010

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Abstract

In this paper, the influence of two typical ionic impurities (Na+ and Mg2+) is investigated with the focused beam reflectance measurement (FBRM) technique. In this system, the on-line FBRM is used as a tool for monitoring the crystallization process of cobalamin by measuring the chord length distribution of particles and the particle counts. It is noted that impurity Mg2+ has a more significant effect than Na2+ in crystal growth of the whole crystallization process. From the microscopic observation of crystals, Mg2+ has an obvious effect on the crystal habit, while Na2+ has little effect. In addition, the crystal habit changes can be monitored by particle vision measurement (PVM). Understanding these effects is helpful to aid optimization and improve process control.

Cite this article

Baoli SHAO, Hui CHEN, Shuang WANG, Haijun WANG, Shenmin XU, . Effects of ionic impurities on crystallization of cobalamin[J]. Frontiers of Chemical Science and Engineering, 2010 , 4(1) : 70 -74 . DOI: 10.1007/s11705-009-0293-3

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