1.School of Chemistry and
Chemical Engineering, Tianjin University of Technology, Tianjin 300384,
China; 2.School of Chemistry and
Chemical Engineering, Tianjin University of Technology, Tianjin 300384,
China；School of Chemical Engineering
and Technology, Tianjin University, Tianjin 300072, China;
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History+
Published Online
2010-03-05
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(242KB)
Abstract
In this paper, the influence of two typical ionic impurities (Na+ and Mg2+) is investigated with the focused beam reflectance measurement (FBRM) technique. In this system, the on-line FBRM is used as a tool for monitoring the crystallization process of cobalamin by measuring the chord length distribution of particles and the particle counts. It is noted that impurity Mg2+ has a more significant effect than Na2+ in crystal growth of the whole crystallization process. From the microscopic observation of crystals, Mg2+ has an obvious effect on the crystal habit, while Na2+ has little effect. In addition, the crystal habit changes can be monitored by particle vision measurement (PVM). Understanding these effects is helpful to aid optimization and improve process control.
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(242KB)
