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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Received date: 04 Jan 2009
Accepted date: 06 Mar 2009
Published date: 05 Sep 2009
Copyright
A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by 1H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound 13, 16, 18, 19, 21, 22, and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B3 in VERO cells.
Key words: benzimidazole; coxsackie virus B3; antiviral properties
Xianjin LUO , Zhonglü ZHANG , Yutian YANG , Fei XUE , Naiyun XIU , Yuanbin SHE . Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives[J]. Frontiers of Chemical Science and Engineering, 2009 , 3(3) : 305 -309 . DOI: 10.1007/s11705-009-0021-z
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