Frontiers of Chemical Science and Engineering >

2009 , Vol. 3 >Issue 3: 305 - 309

DOI: https://doi.org/10.1007/s11705-009-0021-z

RESEARCH ARTICLE

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

  • Xianjin LUO , 1 ,
  • Zhonglü ZHANG 1 ,
  • Yutian YANG 1 ,
  • Fei XUE 1 ,
  • Naiyun XIU 2 ,
  • Yuanbin SHE , 3
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  • 1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • 2. Schools of Life Science and Environmental Science, Shanghai Normal University, Shanghai 200234, China
  • 3. Institute of Green Chemistry and Fine Chemicals, Beijing University of Technology, Beijing 100022, China

Received date: 04 Jan 2009

Accepted date: 06 Mar 2009

Published date: 05 Sep 2009

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by 1H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound 13, 16, 18, 19, 21, 22, and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B3 in VERO cells.

Key words： benzimidazole; coxsackie virus B3; antiviral properties

Cite this article

Xianjin LUO , Zhonglü ZHANG , Yutian YANG , Fei XUE , Naiyun XIU , Yuanbin SHE . Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives[J]. Frontiers of Chemical Science and Engineering, 2009 , 3(3) : 305 -309 . DOI: 10.1007/s11705-009-0021-z

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