Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Abstract

A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by ¹H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound 13, 16, 18, 19, 21, 22, and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B₃ in VERO cells.

Keywords

benzimidazole / coxsackie virus B₃ / antiviral properties

References

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Higher Education Press and Springer-Verlag Berlin Heidelberg