Frontiers of Chemical Science and Engineering >

2011 , Vol. 5 >Issue 1: 55 - 59

DOI: https://doi.org/10.1007/s11705-010-0537-2

RESEARCH ARTICLE

Synthesis and characterization of norfloxacin biomonomer

  • Shengxiong DONG , 1,2,3 ,
  • Qiaoping CHEN 1 ,
  • Hongfang XIE 1 ,
  • Jianhua HUANG 1,2,3
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  • 1. Department of Chemistry and Environmental Science, Ningde normal University, Ningde 352100, China
  • 2. College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China
  • 3. Fujian Provincial Key Laboratory of Polymer Materials, Fuzhou University, Fuzhou 350108, China

Received date: 22 Nov 2009

Accepted date: 20 Apr 2010

Published date: 05 Mar 2011

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

A novel drug agent named norfloxacin biomonomer was developed in order to solve the problem of low drug content, uneven drug distribution, low molecular weight, and wide molecular weight distribution of polymer drug, based on polyurethane, which was used as an antibacterial agent to control the bacterial infection associated with biofilm formation on polymeric materials used in biologic environments. In this research, norfloxacin biomonomer was synthesized by esterifying the compound of norfloxacin. High-performance liquid chromatography system was used to analyze the purity of the final product and intermediate products, and Fourier transform infrared spectrometer and mass spectrum were used to verify the final product and intermediate products. The results showed that the objective product was developed successfully. The final product of norfloxacin biomonomer could be incorporated into the polyurethane as chain extender.

Key words： norfloxacin; biomonomer; synthesis; characterization

Cite this article

Shengxiong DONG , Qiaoping CHEN , Hongfang XIE , Jianhua HUANG . Synthesis and characterization of norfloxacin biomonomer[J]. Frontiers of Chemical Science and Engineering, 2011 , 5(1) : 55 -59 . DOI: 10.1007/s11705-010-0537-2

Acknowledgments

This work was supported by the program of the Fujian Provincial Department of Science & Technology (No.2006I0019) and supported by the Science and Technology Department of Fujian Province Subsidization Provincial University Projects (2008F50502) and the Fujian Provincial Key Laboratory of Polymer Materials.

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