Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

Abstract

The utilization of poly (2-hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic acid was investigated. Grafted copolymers of 2-hydroxyethylmethacrylate (HEMA) monomers on agar were synthesized by microwave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. t₅₀ (the time taken for release of 50% of the enclosed drug) value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P(HEMA) appears to be a useful matrix for controlled release.

Key words： agar; controlled drug release; 5-Amino salicylic acid; poly(2-hydroxyethylmethacrylate) grafted agar

Acknowledgement

The authors acknowledged the financial support received from the University Grant Commission, New Delhi, India vides (Grant No. F-39-800/2010(SR)) and Department of Science and Technology, New Delhi (Grant No. 08/12-09141).

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