RESEARCH ARTICLE

Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

  • G. Usha RANI ,
  • Kartick Prasad DEY ,
  • Srijita BHARTI ,
  • Sumit MISHRA
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  • Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India

Received date: 14 Jul 2014

Accepted date: 20 Oct 2014

Published date: 14 Jan 2015

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

The utilization of poly (2-hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic acid was investigated. Grafted copolymers of 2-hydroxyethylmethacrylate (HEMA) monomers on agar were synthesized by microwave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. t50 (the time taken for release of 50% of the enclosed drug) value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P(HEMA) appears to be a useful matrix for controlled release.

Cite this article

G. Usha RANI , Kartick Prasad DEY , Srijita BHARTI , Sumit MISHRA . Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar[J]. Frontiers of Chemical Science and Engineering, 2014 , 8(4) : 465 -470 . DOI: 10.1007/s11705-014-1452-8

Acknowledgement

The authors acknowledged the financial support received from the University Grant Commission, New Delhi, India vides (Grant No. F-39-800/2010(SR)) and Department of Science and Technology, New Delhi (Grant No. 08/12-09141).
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