Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

G. Usha RANI, Kartick Prasad DEY, Srijita BHARTI, Sumit MISHRA

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Front. Chem. Sci. Eng. ›› 2014, Vol. 8 ›› Issue (4) : 465-470. DOI: 10.1007/s11705-014-1452-8
RESEARCH ARTICLE

Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

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Abstract

The utilization of poly (2-hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic acid was investigated. Grafted copolymers of 2-hydroxyethylmethacrylate (HEMA) monomers on agar were synthesized by microwave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. t50 (the time taken for release of 50% of the enclosed drug) value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P(HEMA) appears to be a useful matrix for controlled release.

Keywords

agar / controlled drug release / 5-Amino salicylic acid / poly(2-hydroxyethylmethacrylate) grafted agar

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G. Usha RANI, Kartick Prasad DEY, Srijita BHARTI, Sumit MISHRA. Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar. Front. Chem. Sci. Eng., 2014, 8(4): 465‒470 https://doi.org/10.1007/s11705-014-1452-8

References

[1]
Park K, Randall J M. Controlled Drug Delivery: Present and Future. ACS Symposium Series, 2000, Vol. 752, Chapter 1, 2–12
[2]
Vyas S P, Khar R K. Controlled Drug Delivery: Concepts and Advances. Delhi: Vallabh Prakashan, 2002
[3]
Fordtran J S, Locklear T W. Ionic constituents and osmolality of gastric and small-intestinal fluids after eating. The American Journal of Digestive Diseases, 1966, 11(7): 503–521
[4]
Watson B W, Meldrum S J, Riddle H C, Bown R L, Sladen G E. pH profile of Gut as measured by radiotelemetry capsule. British Medical Journal, 1972, 2(5805): 104–106
[5]
Evans D F, Pye G, Bramley R, Clark A G, Dyson T J, HardcastleJ D. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut, 1988, 29(8): 1035–1041
[6]
Parkl K, Randall M J. Controlled Drug Delivery: Present and Future. Washington DC: American Chemical Society, 2000
[7]
Anirudhan T S, Sandeep S. Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery. New Journal of Chemistry, 2011, 35: 2869–2876
[8]
Cheng S H, Liao W N, Chen L M, Lee C H. pH-controllable release using functionalized mesoporous silica nano particles as an oral drug delivery system. Journal of Materials Chemistry, 2011, 21: 7130–7137
[9]
Ardizzone S, Porro G B. A practical guide to the management of distal ulcerative colitis. Drugs, 1998, 55(4): 519–542
[10]
Cheng G, An F, Zou M J, Sun J, Hao X H, He Y X. Time- and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World Journal of Gastroenterology, 2004, 10(12): 1769–1774
[11]
Kinget R, Kalala W, Vervoort L, van den Mooter G. Colonic drug targeting. Journal of Drug Targeting, 1998, 6(2): 129–149
[12]
Kohane S D, Langer R. Biocompatibility and drug delivery systems. Chemical Science, 2010, 1: 441–446
[13]
Mino G, Kaizerman S. New method for the preparation of graft copolymers. Polymerization initiated by ceric ion redox systems. Journal of Polymer Science. Polymer Physics Edition, 1958, 31(122): 242–243
[14]
Thakur V K, Singha A S. Rapid synthesis, characterization and physicochemical analysis of biopolymer based graft copolymer. International Journal of Polymer Analysis and Characterization, 2011, 16(3): 153–164
[15]
Mishra S, Sen G, Rani G U, Sinha S. Microwave assisted synthesis of polyacrylamide grafted agar (Ag-g-PAM) and its application as for wastewater treatment. International Journal of Biological Macromolecules, 2011, 49(4): 591–598
[16]
Rani G U, Mishra S, Pathak G, Jha U, Sen G. Synthesis and applications of poly(2-hydroxyethylmethacrylate) grafted agar: A microwave based approach. International Journal of Biological Macromolecules, 2013, 61: 276–284
[17]
Sen G, Rani G U, Mishra S. Microwave assisted synthesis of Poly(2-hydroxyethylmethacrylate) grafted Agar (Ag-g-P(HEMA)) and its application as a flocculant for wastewater treatment. Frontiers of Chemical Science and. Engineering, 2013, 7(3): 312–321
[18]
Benson R S. Use of radiation in biomaterials science. Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, 2002, 191(1-4): 752–757
[19]
Casimiro M H, Leal J P, Gil M H. Characterisation of gamma irradiated chitosan/pHEMA membranes for biomedical purposes. Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, 2005, 236(1-4): 482–487
[20]
Ferreira L M, Rocha J M S, Andrade M E, Gil M H. Preparation and characterization of polyethylene based graft copolymers. Applications in the immobilization of enzymes. Radiation Physics and Chemistry, 1998, 52(1-6): 207–212
[21]
Rani G U, Mishra S, Sen G, Jha U. Polyacrylamide grafted agar: Synthesis and applications of conventional and microwave assisted technique. Carbohydrate Polymers, 2012, 90(2): 784–791
[22]
Sen G, Mishra S, Jha U, Pal S. Microwave initiated synthesis of polyacrylamide grafted guar gum (GG-g-PAM) –characterizations and application as matrix for controlled release of 5-amino salicylic acid. International Journal of Biological Macromolecules, 2010, 47(2): 164–170
[23]
Rani G U, Konreddy A K, Mishra S, Sen G. Synthesis and applications of polyacrylamide grafted agar as a matrix for controlled drug release of 5-ASA. International Journal of Biological Macromolecules, 2014, 65: 375–382
[24]
Sen G, Pal S. Microwave initiated synthesis of polyacrylamide grafted carboxymethylstarch (CMS-g-PAM): Application as a novel matrix for sustained drug release. International Journal of Biological Macromolecules, 2009, 45(1): 48–55
[25]
Marinich J A, Ferrero C, Jiménez-Castellanos M R. Graft copolymers of ethyl methacrylate on waxy maize starch derivatives as novel excipients for matrix tablets: Physicochemical and technological characterization. European Journal of Pharmaceutics and Biopharmaceutics, 2009, 72(1): 138–147
[26]
Singh B, Chauhan G S, Bhatt S S K, Kumar K. Metal ion sorption and swelling studies of psyllium and acrylic acid based hydrogels. Carbohydrate Polymers, 2006, 64(1): 50–56
[27]
Peppas N A, Franson N M. The swelling interface number as a criterion for prediction of diffusional solute release mechanisms in swellable polymers. Journal of Polymer Science and Polymer Physics, 1983, 21(6): 983–997
[28]
Ritger P L, Peppas N A. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. Journal of Controlled Release, 1987, 5(1): 37–42
[29]
Geresh S, Gdalevsky G Y, Gilboa I, Voorspoels J, Remon J P, Kost J. Bioadhesive grafted starch copolymers as platforms for peroral drug delivery: A study of theophylline release. Journal of Controlled Release, 2004, 94(8): 391–399
[30]
Peppas N A. Analysis of Fickian and non-Fickian drug release from polymers. Pharmaceutica Acta Helvetiae, 1985, 60(4): 110–112
[31]
Song C X, Labhasetwar L, Levy R J. Controlled release of U-86983 from double-layer biodegradable matrices: Effect of additives on release mechanism and kinetics. Journal of Controlled Release, 1997, 45(21): 177–192

Acknowledgement

The authors acknowledged the financial support received from the University Grant Commission, New Delhi, India vides (Grant No. F-39-800/2010(SR)) and Department of Science and Technology, New Delhi (Grant No. 08/12-09141).

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2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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