Transmission of antibiotic resistance genes in agroecosystems: an overview

Abstract

The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.

Keywords

agroecosystem / antibiotic resistance / public health / soil-plant system

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Acknowledgements

This work was funded by the Australian Research Council (DP170103628) and the Australia-China Joint Research Centre project on Healthy Soils for Sustainable Healthy Food Production and Environmental Quality (ACSRF48165).

Compliance with ethics guidelines

Jizheng He, Zhenzhen Yan, and Qinglin Chen declare that they have no conflicts of interest or financial conflicts to disclose.

This article is a review and does not contain any studies with human or animal subjects performed by any of the authors.

RIGHTS & PERMISSIONS

The Author(s) 2020. Published by Higher Education Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)