A brief review of genome editing technology for generating animal models

Abstract

The recent development of genome editing technologies has given researchers unprecedented power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animal models. This mini-review briefly summarizes the development of major genome editing tools, focusing on the application of these tools to generate animal models in multiple species.

Keywords

animal model / CRISPR / genome editing / TALEN / ZFN

References

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Compliance with ethics guidelines

Haoyi Wang, Sen Wu, Mario R. Capecchi, and Rudolf Jaenisch declare that they have no conflicts of interest or financial conflicts to disclose.

This article is a mini-review and does not contain any studies with human or animal subjects performed by any of the authors.

RIGHTS & PERMISSIONS

The Author(s) 2020. Published by Higher Education Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)