The past, present and future of bovine pluripotent stem cells: a brief overview

Abstract

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purpose of gene-targeting, true pluripotent stem cells in this economically important species are still elusive. With the rapid advances in genome-editing and cloning using homologously recombined somatic cells, the need for pluripotent stem cells for precise genetic modification in any species became questionable. With the pig being the better model for human regenerative biology, the identification of the commonalities and uniqueness of the pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells in the bovine.

Keywords

bovine / embryonic / induced / pluripotent stem cells

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Acknowledgements

This work was supported by grants from the United States Department of Agriculture (1265-31000-091-2S and W317).

Compliance with ethics guidelines

ƒXiuchun Tian declare that he has no conflicts of interest or financial conflicts to disclose.ƒThis article is a review and does not contain any studies with human or animal subjects performed by the author.

RIGHTS & PERMISSIONS

The Author(s) 2018. Published by Higher Education Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)