Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Abstract

DNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development. Complex DNA damage, double-strand breaks, represents a more difficult repair process and involves various repair pathways. Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation.

Keywords

DNA damage / double-strand breaks (DSBs) / oocyte / embryo

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (31171376 and 31401276), National Basic Research Program of China (2012CB944401).

Compliance with ethics guidelinesƒShen Yin, Junyu Ma and Wei Shen declare that they have no conflict of interest or financial conflicts to disclose.ƒThis article is a review and does not contain any studies with human or animal subjects performed by any of the authors.

RIGHTS & PERMISSIONS

Higher Education Press and Springer-Verlag Berlin Heidelberg