Pertinent data of 501 cases of insulinoma collected from a nationwide survey in China are reported and compared with Stefanini’s series collected from other countries.

Experiences in the diagnosis and treatment of insulinoma in China are discussed.

Eine von uns entwickelte Methode zur Bestimmung der Compliance der Arteria pulmonalis (C_{p a}) wird dargestellt. Aus der Höhe der systolischen Welle in der dZ-Kurve des Impedanz-Pulmonal-Rheogramms und aus der Druckamplitude der Arteria pulmonalis kann man C_{p a} berechnen: C_{p a} =H/dP x 124,37+2,56 (ml/mm Hg).

Bei “Beine hoch” und unter Belastung fällt C_{p a} ab, weil der Anstieg des Schlagvolumens dabei zur Vergrößerung des dP führt. Bei Patienten mit pulmonaler Hypertonie vergrößert sich dp und vermindert sich H infolge der Erhöhung des Lungengefäßwiderstandes und von P_{p a}; dadurch nimmt C_{p a} ab.

In diesem Artikel wird über 10 Arten von Saugwürmern innerhalb von 5 Familien, 8 Gattungen, berichtet, die in 93 Tieren im. Waldgebiet Shennongjia, Provinz Hubei, China, gefunden wurden, nämlich Platynotrema hubeiense sp. nov., Lyperosomum armenicum, Brachylecithum attenuatum, Pagumogonimus veocularis, Pagumogonimus skrjabini syn. Paragonimus szechuanensis, Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Eurytrema coelomaticum und Ogmocotyle sikae.

Die erste Art ist noch nicht beschrieben, sie wurde von uns “Platynotrema hubeiense sp. nov.” benannt. Ihre morphologischen Charakteristika sind: Bauchsaugnapf größer als Mundsaugnapf, Ösophagus verhältnismäßig lang, Ovarium dicht am hinteren Rand des Bauchsaugnapfs, Eidotterdrüse gut entwickelt, erstreckt sich über die beiden mittleren Viertel der Körperlänge, Eier relativ klein. Exemplare dieser Würmer sind im Institut für Parasitologie der Wuhan-Medizinischen Hochschule zu sehen.

5 Spezies (Pagumogonimus skrjabini syn. Paragonimus szechuanensis, Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Eurytrema coelomaticum) können den Menschen infizieren; für diese 5 Arten ist Shennongjia ein natürlicher Infektionsherd. Deshalb sind, um während der Entwicklung der Forstwirtschaft Zoonosen zu verhüten, parasitologische Untersuchungen in den Waldgebieten von großer praktischer Bedeutung.

This paper is a report on the histopathological changes of the inner ear following artificial rupture of the left round window membrane observed in 19 experimental guinea pigs.

We found that the artificially perforated round window membrane could heal spontaneously, that no noticeable morphological changes took place in Corti’s organ within 2 weeks postoperatively and that if the round window membrane rupture failed to heal 2.5 months postoperatively, the Corti’s organ in the basic turn would be the chief part to be damaged, as a result of which the high frequency hearing ability might be impaired. These findings call the clinicians’ attention to the fact that if the hearing of patients who are suspected of labyrinthine window membrane rupture does not improve distinctly 2 weeks after the appearance of the symptoms, operations must be performed immediately for exploration and repair.

From Sept. 26, 1980 to Apr. 25, 1981, 74 heterotopic heart transplantations in rats (54 preparatory and 20 formal experiments) have been performed by modified Abbott-Ono’s method.

Hybrid male rats were used as recipients and donors. By using micro-surgical technique (10 x) all vascular anastomoses were done satisfactorily. The thoracic aorta of the donor heart was anastomosed end-to-side to the abdominal aorta of the recipient, the pulmonary artery of the donor heart to the abdominal inferior vena cava of the recipient in the same manner, and the other vessels of the donor heart were ligated. Following revascularization, effective ventricular contraction appeared spontaneously within 2 minutes. No artificial pacemaker was needed for resuscitation.

Of the 20 transplanted animals, 14 survived more than 7 days (70%) and 8 more than 14 days (40%) without immunosuppressive therapy; the longest survivor lasted for more than one year with the mean survival time being 9 days. Pathological examinations showed that 12 transplanted hearts (60%) had definite histological evidences of rejection.

The effects of tetrandrine, verapamil, propranolol and practolol on isoproterenol dose-response relationships and influence of tetrandrine, verapamil and nifedipine on calcium dose-response relationships and on excitation-contraction coupling were investigated in isolated cat papillary muscles.

Propranolol and practolol competitively antagonized isoproterenol. Tetrandrine and verapamil also antagonized isoproterenol but in a non-competitive manner. Tetrandrine, verapamil and nifedipine shifted calcium dose-response curves to the right, and acted as non-competitive antagonists of calcium, as a plot of log (x-1) vs.log [B] resulted in straight lines with slopes of -0.43, -0.55 and -0.42, respectively.

Tetrandrine, verapamil and nifedipine resulted in excitation-contraction uncoupling. It is suggested that tetrandrine inhibited the inward displacement of calcium through the voltage-dependent channel.

The results are consistent with our previous supposition that tetrandrine is a calcium antagonist of plant origin.

Mittels histochemischer, histopathologischer und elektronenmikroskopischer Untersuchungen konnten wir zeigen, daß Angelica sinensis (oliv) Diels eine protektive Wirkung auf die durch D-Galaktosamin geschädigten Leberzellen ausübt. Außerdem hat Angelica sinensis auf die durch D-Galaktosamin induzierte Erniedrigung des Glykogengehaltes eine hemmende Wirkung. Es lohnt sich daher, über diese Probleme und über die bei der Leberschädigung wirksamen Substanzen von Angelica sinensis und den Wirkungsmechanismus derselben weiter zu forschen.

From the fruit of Rhododendron molle G.Don an active principle has been isolated, which possesses antihypertensive and bradycardiac actions and has been used clinically for severe hypertension with good results. The active principle rhomotoxin has been proved to be the same as rhodojaponin-III by physical and chemical identification.

The impedance pulmonary rheogram (IPR) and its first derivation of 83 patients with chronic cor pulmonale (CCP) and 50 healthy persons were measured and analyzed. The results indicated that the following parameters are valuable in the diagnosis of CCP: 1. Q-b interval ≥ 0.15 sec; 2.RVET ≤ 0.28 sec; 3. Q-b/RVET ratio ≥ 0.46; 4. Q-b index ≥ 0.17; 5. Q-C interval ≥ 0.20 sec; 6. wave amplitude ≤ 0.15 ohm. When any three of the above-mentioned six indices are positive, the patient may be diagnosed as CCP. According to this standard the rate of early diagnosis of CCP was 73.6%.

By a series of toxicological experiments, including studies on chronic toxicity, teratogenesis and reproduction, Ames’ assay and carcinogenic observation, the non-effective level of tetrachlorvinphos (TCVP) was determined to be 0.15 mg/kg wt. Based on this, the acceptable daily intake for an adult was calculated to be 0.9 mg, including 9% (i.e. 0.081 mg) from drinking water. If an adult takes 3 liters of water per day, the concentration of TCVP in water should be 0.027 mg/1, approximately 0.03 mg/1. Both the requirements of the effects of TCVP on the organoleptic characteristics and self-purification processes in surface water can also be satisfied with 0.03 mg/1. Thus, the authors suggest that the maximum permissible concentration of TCVP in surface water could be established as 0.03 mg/1.

The experimental results showed that the fecal coliform (FC) to fecal streptococcus (FS) ratio (FC/FS) in the human feces and in warm-blooded animal feces were rather different. FC/FS ratio in the human feces was greater than 7.0, and in warm-blooded animal feces was less than 1.0. Therefore, under certain conditions, the FC/FS ratio of polluted water may be used as an index to distinguish human fecal pollution from animal fecal pollution.