This article presents our experiences in hepatic resection of 467 cases over a period of 22 years with a total operative mortality of 4.0%. Of the 467 cases, malignancies were found in 288 cases, benign lesions in 179 cases; extensive hemihepatectomy was done in 194 cases, and lobectomy or partial resection in 273 cases. Follow-up results: The cases of non-malignant tumors are living well. In cases of metastatic liver cancer, the mean survival time was 1.4 years. The 5-year survival rate of primary liver cancer was 24.8%, while that of the malignant tumors sized less than 5 cm in diameter amounted to 53.8%. In this paper, the authors focussed the discussion on the selection of patients, judgment of the resectability of tumor during operation, improvements in operative technic and the prevention and treatment of surgical complications.

VLDLs isolated from the normolipidemic rat or monkey and the hyperlipidemic rat stimulated the incorporation of₁₄C-oleic acid into triglyceride of the mouse peritoneal macrophages. The magnitude of this stimulating effect depended upon the concentration of lipoproteins in the medium. Experiments using₁₂₅I labeled VLDLs revealed that the binding of normolipidemic VLDL with the macrophage was saturable, and unlabeled VLDL competed effectively with the labeled VLDL. These results suggested that on the surface of the macrophages there are special binding sites for the VLDL. It is possible that separate receptors are responsible for either the normolipidemic or the hyperlipidemic VLDL.

The hyperlipidemic VLDL from rat or monkey enhanced the synthesis of₁₄C-cholesterol ester. After binding with the macrophage, the different VLDLs caused accumulation of either triglyceride or cholesterol ester or both. The possible interpretation is that it depends upon the lipid composition of that VLDL, especially the ratio of triglyceride versus cholesterol ester.

The present study supports the concept that at least a part of the foam cells derive from the macrophage, i.e., the macrophage plays an important role in the formation of the atherosclerotic lesion. In addition, the binding and degradation of the normolipidemic VLDL by the macrophage may be of physiological importance in the metabolism of VLDL.

64 male rats were divided into two groups and fed on the diet containing, as percentage of dietary energy, 20% protein, 50% carbohydrate and 30% fat, which composed of undecanoin: caprin: soyabean oil (45:45:10 V/V/V) for the experimental group and soyabean oil only for the control group. At the end of the 8th week, 8 animals of each group were sacrificed after fasting 4, 24, 48 and 72 hours respectively.

Since the terminal three-carbon residue of the odd-numbered medium chain fatty acids (OMFA) was glucogenic, OMFA enriched rats possessed a potential source of gluconeogenetic precusors, thus the blood glucose and immunoreactive insulin (IRI), perhaps the liver glycogen of those rats maintained at higher level as compared with the controls.

In brief, the present study revealed that OMFA could be deposited into as well as mobilized from the adipose tissue. During prolonged starvation OMFA was catabolized rapidly.

In this study, we attempt to analyze the data of two-dimensional echocardiography and systolic time intervals in 21 patients with documented coronary artery disease. No dysfunction of ventricular wall motion was found in any of the 4 patients with angina pectoris at rest. Abnormal segmental ventricular wall motions were observed in the other 17 patients with myocardial infarction. The apical region was involved in 13 cases and the dyskinesis accounted for 33.9 per cent of the total number of abnormal segments. Left ventricular wall motion index was closely correlated with systolic time intervals, including PEP, LVET and PEP/LVET. The correlation coefficients were-0.72, 0.85 and-0.80 respectively. It has been suggested that left ventricular wall motion index is a valuable one for evaluating left ventricular function and that systolic time intervals can reflect indirectly the presence and severity of abnormal ventricular segmental motion in patients with myocardial infarction.

A combination and improvement of Sweet’s method and Baltin’s method for intraocular foreign body localization designed by us is presented and its clinical application described in detail. In addition, we introduce an improvement of bone-free radiography of the eye, in which the bone-free portion radiographed is significantly larger than that obtained by means of Vogt’s method; and as the non-screen film is placed outside of the lateral wall of the orbit instead of being stuck into the orbit, the patient feels no discomfort. A method of measurement and calculation of 2 points in space is recommended to replenish the coordinate chart method to determine correctly whether the foreign body is inside or outside of the eye-ball. All these new methods mentioned in this paper have been proved safe, simple and convenient.

Galvinoxyl is a long-lived free radical and a highly efficient scavenger of shorter-lived free radicals. In vitro studies demonstrated that galvinoxyl has an inhibitory effect on tumor cells of sarcoma 180 and ascitic form of hepatoma. The higher the concentration of galvinoxyl, the more remarkable its inhibiting effect. Growth of the hepatoma cells in vivo was also inhibited when they had been treated in vitro with galvinoxyl. Galvinoxyl showed an inhibition rate of 43.1%.

6 days after implantation of tumor cells into mice an intralesional injection of galvinoxyl was given and the same was repeated 4 days later. It was found that galvinoxyl showed an inhibition rate of 51.3% on subcutaneously implanted sarcoma 180.

Das Lipoprotein der Leberzellmembran, das LSP, wurde durch Chromographie nach der Methode, die von McFarlane beschrieben wurde, aus normalem Lebergewebe isoliert. Zur Charakterisierung des isolierten LSP-Präparates wurde Polyakrylamid-Gel-Elektrophorese durchgeführt. Enzym-gekoppeltes Staphylokokken-Protein A Immunosorbens Assay (SPA-ELISA) mit dem gereinigten LSP-Präparat als Antigen wurde zur Bestimmung von Anti-LSP-Antikörper in Seren von Patienten verwendet. Insgesamt wurden 277 Serumproben untersucht. Die Resultate der Untersuchungen in der Hepatitis-Gruppe zeigten, da\ die Nachweisrate von Anti-LSP bei Patienten mit schwerer Hepatitis am höchsten (8/9) und bei Patienten mit CAH die nächsthöchste (75%) war. Die Nachweisrate von Anti-LSP in Seren von Patienten mit AH, CPH und von HBsAg-Trägern betrug 47,6%, 38,4% bzw. 30,4%. In den Seren von 46 Normalpersonen zeigte sich aber nur ein Fall Anti-LSP-positiv. In der Gruppe mit anderen Erkrankungen war Anti-LSP positiv in 8 von 13 Fällen mlt Leberzirrhose, 5 von 7 Fällen mit SLE und 2 von 7 Fällen mit chronischer Nephritis. Die Resultate der Untersuchungen zeigten, da\ SPA-ELISA eine empfindliche Methode ist, die in der Klinik leicht durchgeführt werden kann. Es bestand eine Korrelation zwischen den Nachweisraten bzw. den Titern von Anti-LSP und Leberschädigung bei Hepatitis. Die Bestimmung von Anti-LSP dürfte deshalb eine brauchbare Methode zur Beurteilung der Leberschädigung bei Patienten mit Hepatitis sein.

Die immunopathologische Bedeutung von LSP und Anti-LSP-Antikörper bei der chronischen Hepatitis wird diskutiert.

By recording the neuron unit discharges we have observed the effect of iontophoresis of gamma amino butyric acid (GABA) and glycine on the electrical activity of three different types of neurons in mesencephalic reticular formation (MRF). The results indicated that both GABA and glycine have a significant inhibitory effect on the spontaneous discharges of all three types of neurons and the pain discharges of the “pain excitatory type” neurons, and this inhibitory effect can be abolished by their corresponding antagonists, picrotoxin and strychnine. In combination with known histochemical data the results suggest that GABA and glycine might be endogenous transmitters in MRF.

Iontophoresis of picrotoxin and strychnine can abolish the inhibitory effect of electro-acupuncture (EA) of pain discharges. This suggests that in mesencephalon there might exist endogenous GABA and glycine which might participate in analgesic mechanism. However, equal amount of picrotoxin and strychnine has no significant effect on the pain inhibitory response of “pain inhibitory type” neurons. This indicates that this response might have no direct relation to GABA and glycine.