Experimental studies on the antitumor action of free radicals: Antitumor action of galvinoxyl

Abstract

Galvinoxyl is a long-lived free radical and a highly efficient scavenger of shorter-lived free radicals. In vitro studies demonstrated that galvinoxyl has an inhibitory effect on tumor cells of sarcoma 180 and ascitic form of hepatoma. The higher the concentration of galvinoxyl, the more remarkable its inhibiting effect. Growth of the hepatoma cells in vivo was also inhibited when they had been treated in vitro with galvinoxyl. Galvinoxyl showed an inhibition rate of 43.1%.

6 days after implantation of tumor cells into mice an intralesional injection of galvinoxyl was given and the same was repeated 4 days later. It was found that galvinoxyl showed an inhibition rate of 51.3% on subcutaneously implanted sarcoma 180.

Keywords

free radical / scavenger of free radical / galvinoxyl / antitumor action

References

[1] ShambergerRT, et al. . Protection against cocarcinogenesis by antioxidants. Experientia, 1966, 22116-116

[2] BartlettPD, FunahashiT. Galvinoxyl (2,6-di-tert-butyl-a-(3.5-di-tert-butyl-4-0x0-2, 5-cyclohexadiene-l-ylidene)-P tolyloxy) as a scavenger of shorter-lived free radicals. J Am Chem Soc, 1962, 84(13): 2596-2596

[3] 38(3): 213, 1980

[4] (i RNA) (4): 327, 1981

[5] 324–327, 7979