The hemodynamic changes of THBF (total hepatic blood flow), portography after PCDV (pericardial devascularization) and the cephalad portasystemic collaterals in the bleeders are reviewed. In 78 cases with bleeding varices, including 24 re-bleeders, the occurrence of coronary varices (88.46%) is much higher than that of short gastric varices (34.61%). There is a very significant difference between the two (P < 0.001). In analysing the relationship between the coronary varices in portography and bleeding of the esophageal varices pre and post-PCDV, we have recognized the role of the lesser splanchnic circulation of the portal system, especially the coronary vein, in the formation of the esophageal varices and bleeding. The value of THBF is 13.49 ± 0.84 (SE) m1/min/kg preoperatively and is increased to 15.96 ± 1.04(SE) m1/min/kg postoperatively. The postoperative value is increased by 18.31% (P < 0.01). Hemodynamically, PCDV is a rational procedure, which can not only control the variceal bleeding, but also increases hepatic blood perfusion.

In 19 anesthetized open-chest dogs the effects of tetrandrine on experimental myocardial infarction were investigated by epicardial mapping and creatine phosphate kinase (CPK) enzyme estimation. In epicardial mapping the ΣST and NST in dogs pretreated with tetrandrine were significantly lower than the control group after 15–30 minutes following ligation of the left anterior descending artery (LAD). The difference of ΣST, NST in both groups reached peak value at 2 hours. If taking the ΣST and NST 2 minutes after ligation as 100%), ΣST in the treated dogs 2 hours after ligation would be 43% vs 91% in the control group, NST in the treated dogs 53% vs 90% in the control group. 24 hours after ligation of LAD the CPK of preserved myocardium of infarcted area in the treated dogs was more than in the control group. The CPK released to blood was obviously less in treated group. These suggested that tetrandrine had some protective effects on experimental myocardial infarction. But because the number of dogs studied was small and the effect on clinical myocardial infarction might be different from experimental model, these observations warrant further investigation.

In this study we attempt to define the result of pancreas transplantation with the duct left open to drain freely into the peritoneal cavity. Twenty dogs underwent total pancreatectomy, splenectomy, and segmental pancreas transplantation with this technique. Eighteen of the twenty animals recovered normal blood sugar and serum insulin levels 24 hrs after operation. Up to date, the longest survival time is 5 months with excellent pancreatic function. Pancreatic biopsies obtained from animals 45 days after transplantation showed that the islet cells were normal, the acinar tissue was normal on the whole and interlobular connective tissue showed slight proliferation.

In this report we advocate creation of an arteriovenous fistula between the splenic artery and vein at the tail of the graft in order to markedly reduce the incidences of thrombosis in the graft vessels and hemorrhagic pancreatitis.

Our study concludes that segmental pancreas transplantation with unligated duct is a better approach to transplantation of pancreas. This technique is recommended for clinical application.