Clinical value of detecting platelet—associated IgG in patients with idiopathic thrombocytopenic purpura

Abstract

We applied an indirect hemagglutination inhibition test to detect platelet-associated immunoglobulin G (PAIgG). This test is relatively easy to perform and has good reproducibility. The PAIgG value detected with this method in 45 normal donors was 0–5 fg per platelet. In our series there were 15 ITP patients, of whom two had been in complete remission and had normal PAIgG values. In the remaining 13 cases, 11 were found to have increased PAIgG values (more than 5 fg per platelet). In cases where corticosteroids or splenectomy were effective, rising of the platelet count was associated with PAIgG waning.

Preliminary analysis of clinical data of ITP patients suggested that the clinically diagnosed ITP might be of heterogeneous pathogenesis. A further study is warranted.

Keywords

idiopathic thrombocytopenic purpura (ITP) / platelet-associated IgG (PAIgG) / indirect hemagglutination inhibition test

References

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