Clinical observation of haemodynamic effects of rhomotoxin in hypertensive patients

Abstract

The haemodynamic changes of 30 hypertensive patients treated with rhomotoxin were studied with mechanocardiogram. Both PEPI and PEP/LVET were apparently increased in our patients, indicating that the myocardial compliance of the hypertensive patients was reduced and their cardiac function was abnormal to a certain extent. Rhomotoxin reduced the cardiac afterload by lowering the blood pressure (from 192±26/114±14 to 143±25/88±11 mmHg) and slowing the heart rate (from 76±13 to 58±10 beats/min) significantly. Its effects on cardiac phases were mainly to shorten QA₂I, LVETI and PEPI and to prolong SFW, while other parameters such as PEP/LVET, A/EO, EF and Vcf were unchanged. Thus, as the blood pressure of the hypertensive patients was lowered to a significant therapeutic level by rhomotoxin, the left ventricular ejection would be enhanced without depressing myocardial contraction and its pump function. Furthermore, the myocardial oxygen consumption was markedly reduced (P < 0.001), thus rhomotoxin would help to improve the cardiac function in hypertensive patients.

Keywords

rhomotoxin / systolic time intervals / mechanocardiogram

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