A preliminary study of the protective effect of angelica sinensis (oliv) diels against liver damage induced by D—galactosamine in rats

Abstract

Mittels histochemischer, histopathologischer und elektronenmikroskopischer Untersuchungen konnten wir zeigen, daß Angelica sinensis (oliv) Diels eine protektive Wirkung auf die durch D-Galaktosamin geschädigten Leberzellen ausübt. Außerdem hat Angelica sinensis auf die durch D-Galaktosamin induzierte Erniedrigung des Glykogengehaltes eine hemmende Wirkung. Es lohnt sich daher, über diese Probleme und über die bei der Leberschädigung wirksamen Substanzen von Angelica sinensis und den Wirkungsmechanismus derselben weiter zu forschen.

References

[1] KepplerD, et al. . Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol, 1968, 9279-279

[2] CeckerK, et al. , et al. . PopperH, et al. , et al. . Galactosamine induced liver injury. Progress in liver diseases, 1972, New York, Grune & Stratton: 183-183

[3] 5, 1979

[4] D 11(6): 262, 1980

[5] Culling CFA: Handbook of histopathological and histochemical techniques, ed 3, p320, Butterworth Co, 1974

[6] WachsteinM, et al. . Histochemistry of hepatic phosphatases at a physiologic pH with special reference to the demonstration of bile canaliculi. Am J Clin Pathol, 1957, 2713-13

[7] NachlasMM, et al. . Cytochemical demonstration of succinic dehydrogenase by the use of a new p-Nitrophenyl substituted ditetrazole. J Histochem Cytochem, 1957, 5420-420

[8] ChayenJ, et al. . Practical histochemistry, 1973, London, John Wiley & Sons: 70-70

[9] Bancroft JD: Histochemical techniques, ed 2, p234, London 1975

[10] KarnovskyMJ, et al. . A “direct-coloring” thiocholine method for cholinesterases. J Histochem Cytochem, 1964, 12219-219

[11] WachsteinM. Enzymatic histochemistry of the liver. Gastroenterology, 1959, 37525-525

[12] JosephW, et al. . Plasma membranes of mammalian cells. J Cell Biology, 1973, 56275-275

[13] EdwardJ, et al. . Acute infective hepatitis: Fine structural and cytochemical alteration in human liver. Arch Pathol, 1968, 86184-184

[14] SamirK, et al. . Early, reversible plasma membrane injury in galactosamine-induced liver cell death. Am J Pathol, 1975, 79579-579

[15] KoudstaalJ, et al. . A histochemical study about changes in rat liver plasma membrane enzyme activities after galactosamine administration. Histochem, 1976, 6277-77

[16] KrainkiA, et al. . Histochemical studies on carbohydrate metabolism in rat liver after galactosamine administration. Virchows Archiv (Cell Pathol), 1979, 30131-131

[17] ChristopherOR, et al. . Metabolic studies in experimental liver disease resulting from D(+)-galactosamine administration. Biochem J., 1972, 13037-37