Quantitative Biology

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    2018, Vol.6  No.3

    Alternative cleavage and polyadenylation (APA) results in mRNA isoforms with different 3′ UTR lengths. Significance analysis of alternative polyadenylation using RNA-seq (SAAP-RS) is a newly developed computational method that interrogates RNA-seq reads mapped to different 3′ UTR sequences (center) and analyze differential expression of 3′ UTR isoforms. SAAP-RS reveals 3′ UTR length differences among mouse brain cells, including neurons, astrocytes, oligod [Detail] ...

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