Quantitative Biology

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    2018, Vol.6  No.1

    Sequence-specific transcription factors establish a diverse network of protein:DNA contacts to recognize target sites in the genome and fine-tune regulatory output. Closely related proteins within sub-families (e.g., OmpR-family paralogs, profiled in this issue) possess substantial structural and functional similarities, but key “specificity-determining residues” (SDRs) can introduce novel base preferences and global binding modes. This image displays the [Detail] ...

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