This cover art exemplifies the potential and complexity of designing genetic circuits that operate reliably across various biological systems.Central to the visual is a radiant DNA helix,emblematic of the genetic foundation of this scientific domain.Encircling it are varied non-model microbes—extremophiles,gut microbes,and other microbial producers-each uniquely depicted to emphasize their diversity and significance in biological engineering. In the background,the silhouette of a researcher at a high-tech workstation mirrors the rigorous analytical and experimental eforts to develop and evaluate geneticcircuits inthese varied organisms.The blend ofelectronicand digital designs with biological imagery highlights the merging of biotechnology with computational tools,focusing on the enhanced predictability and functionality of synthetic biological parts in different microbial environments. For more details please refer to the article by Qin et al.in pp.129-140.
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