Controllable NO Release for Catheter Antibacteria from Nitrite Electroreduction over the Cu-MOF

Abstract

Implant-associated infections caused by biomedical catheters severely threaten patientsʼ health. The use of electrochemical control on NO release from benign nitrite equipped in the catheter can potentially resolve this issue with excellent biocompatibility. Inspired by nitrite reductase, a Cu-BDC (BDC: benzene-1,4-dicarboxylic acid) catalyst with coordinated Cu(II) sites was constructed as a heterogeneous electrocatalyst to control nitrite reduction to nitric oxide for catheter antibacteria. The combined results of in situ and ex situ tests unveil the key function of interconversion between Cu(II) and Cu(I) species in NO₂ ⁻ reduction to NO. After being incorporated into the actual catheter, the Cu-BDC catalyst exhibits high electrocatalytic activity toward NO₂ ⁻ reduction to NO and excellent antibacteria efficacy with a sterilizing rate of 99.9%, paving the way for the development of advanced metal–organic frameworks (MOFs) electrocatalysts for catheter antibacteria.

Graphical Abstract

Keywords

Heterogeneous electrocatalysis / Nitrite electroreduction / NO-releasing catheter / Antibacterial / MOF material

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