Design and Experiments of Ultrasound Image-Guided Multi-DOF Robot System for Brachytherapy

Abstract

To implant radioactive seeds through a needle precisely and safely, a novel multi-DOF surgical robotic system is presented in this paper for percutaneous prostate intervention through the patient’s perineum under real-time ultrasound image guidance. The proposed robot, which is designed with 9-DOF, consists of a 3-DOF automatic location platform for position adjustment, 2-DOF for automatic ultrasonic probe adjustment mounted with electromagnetic trackers, and 4-DOF for manually adjusting the guided template. Meanwhile, a new registration method based on the quaternion algorithm and least square method is developed, and the needle insertion is performed under the real-time guidance of a navigation system. Furthermore, the robot system has undergone some preliminary experiments with a laser tracker to evaluate the repeatability and accuracy of the robot system. The location error of the puncture needle tip can be controlled under 0.7 mm in air for the whole robotic system. The acquired results endorse the precision of the robot system for prostate seed implantation brachytherapy.

Keywords

Ultrasound image guidance / 9-DOF robot / Navigation system / Repeatability / Registration test

References

[1] Van Gellekom MPR, Moerland MA, Wijrdeman HK, et al. Quality of permanent prostate implants using automated delivery with seedSelectron™ versus manual insertion of RAPID Strands™. Radiother Oncol, 2004, 73(1): 49-56.

[2] van Gellekom MPR, Moerland MA, Battermann JJ, et al. MRI-guided prostate brachytherapy with single needle method: a planning study. Radiother Oncol, 2004, 71(3): 327-332.

[3] Buzurovic I, Podder TK, Yu Y (2010) Prediction control for brachytherapy robotic system. J Robot 2010. doi:10.1155/2010/581840

[4] Buzurovic I, Podder TK, Yu Y. Robotic systems for radiation therapy, 2012, Rijeka: INTECH Open Access Publisher Janeza Trdine 9, Croatia)

[5] Meltsner MA, Ferrier NJ, Thomadsen BR. Observations on rotating needle insertions using a brachytherapy robot. Phys Med Biol, 2007, 52(19): 6027-6037.

[6] Fichtinger G, Fiene JP, Kennedy CW, et al. Robotic assistance for ultrasound-guided prostate brachytherapy. Med Image Anal, 2008, 12(5): 535-545.

[7] Bruyère F, Ayoub J, Arbeille P. Use of a telerobotic arm to perform ultrasound guidance during renal biopsy in transplant recipients: a preliminary study. J Endourol, 2011, 25: 231-234.

[8] Bassan H, Patel RV, Moallem M. A novel manipulator for prostate brachytherapy: design and preliminary results. IFAC Proc Vol, 2006, 39(16): 30-35.

[9] Ho HSS, Mohan P, Lim ED, et al. Robotic ultrasound-guided prostate intervention device: system description and results from phantom studies. Int J Med Robot Comput Assist Surg, 2009, 5(1): 51-58.

[10] Long JA, Hungr N, Baumann M, et al. Development of a novel robot for transperineal needle based interventions: focal therapy, brachytherapy and prostate biopsies. J Urol, 2012, 188(4): 1369-1374.

[11] Bax J, Smith D, Bartha L, et al. A compact mechatronic system for 3D ultrasound guided prostate interventions. Med Phys, 2011, 38(2): 1055-1069.

[12] Fitzpatrick JM. The role of registration in accurate surgical guidance. Proc Inst Mech Eng [H], 2010, 224(5): 607-622.

[13] Wiles AD, Peters TM. Real-time estimation of FLE statistics for 3-D tracking with point-based registration. IEEE Trans Med Imaging, 2009, 28(9): 1384-1398.

[14] Stein D, Monnich H, Raczkowsky J et al (2009) Automatic and hand guided self-registration between a robot and an optical tracking system. In: 14th international conference on advanced robotics (ICAR 2009). Munich, Germany, 2009

[15] Gerber N, Gavaghan KA, Bell BJ, et al. High-accuracy patient-to-image registration for the facilitation of image-guided robotic microsurgery on the head. IEEE Trans Biomed Eng, 2013, 60(4): 960-968.

[16] Deguchi D, Feuerstein M, Kitasaka T, et al. Real-time marker-free patient registration for electromagnetic navigated bronchoscopy: a phantom study. Int J Comput Assist Radiol Surg, 2012, 7(3): 359-369.

[17] Zhang S, Jiang S, Yang Z, et al. 2D ultrasound and 3D MR image registration of the prostate for brachytherapy surgical navigation. Medicine, 2015, 94(40): e1643

[18] Wallner K, Blasko JC, Dattoli M. Prostate brachytherapy made complicated, 2001, Seattle: Smartmedicine Press.

[19] Zhang H, Banovac F, Lin R, et al. Electromagnetic tracking for abdominal interventions in computer aided surgery. Comput Aided Surg, 2006, 11(3): 127-136.

[20] Leotta DF. An efficient calibration method for freehand 3-D ultrasound imaging systems. Ultrasound Med Biol, 2004, 30(7): 999-1008.

[21] Bharat S, Kung C, Dehghan E, et al. Electromagnetic tracking for catheter reconstruction in ultrasound-guided high-dose-rate brachytherapy of the prostate. Brachytherapy, 2014, 13(6): 640-650.

[22] Yu Y, Podder T, Zhang Y et al (2006) Robot-assisted prostate brachytherapy. In: 9th International conference on medical image computing and computer-assisted intervention. Copenhagen, Denmark, 2006, pp 41–49

[23] Najafi M, Abolmaesumi P, Rohling R. Single-camera closed-form real-time needle tracking for ultrasound-guided needle insertion. Ultrasound Med Biol, 2015, 41(10): 2663-2676.