Low-temperature plasma induced grafting of 2-methacryloyloxyethyl phosphorylcholine onto poly(tetrafluoroethylene) films

Abstract

Modification of poly(tetrafluoroethylene) (PTFE) films with 2-methacryloyloxyethyl phosphorylcholine (MPC) was performed by low-temperature plasma treatment and grafting polymerization. Surface properties of PTFE were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectra, X-ray photoelectron spectroscopy (XPS), and static contact angle. The results show that MPC has been grafted onto PTFE film surface successfully. Contact angle for the modified PTFE films in the water decreased from 108° to 58.25°, while surface energy increased from 17.52 mN/m to 45.47 mN/m. The effects of plasma treatment time, monomer concentration and grafting time on degree of grafting were determined. In the meanwhile, blood compatibility of the PTFE films was studied by checking thrombogenic time of blood plasma.

Keywords

low-temperature plasma / poly(tetrafluoroethylene) (PTFE) / grafting / 2-methacryloyloxyethyl phosphorylcholine (MPC)

References

[1] Yamagishi H., Crivello J. V., Belfort C. Development of a novel photochemical technique for modifying poly (arylsulfone) ultrafiltration membranes[J]. Journal of Membrane Science, 1995, 105(3): 237-247.

[2] Tsukagoshi T., Kondo Y., Yoshino N. Protein adsorption and stability of poly(ethylene oxide)-modified surfaces having hydrophobic layer between substrate and polymer[J]. Colloids and Surfaces B: Biointerfaces, 2007, 54(1): 82-87.

[3] Huang N., Yang P., Leng Y. X., et al. Surface modification of biomaterials by plasma immersion ion implantation[J]. Surface and Coatings Technology, 2004, 186(1/2): 218-226.

[4] Mowery K. A., Schoenfisch M. H., Saavedra J. E., et al. Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release[J]. Biomaterials, 2000, 21(1): 9-21.

[5] Wu S. Y., Kang E. T., Neoh K. G., et al. Surface modification of poly (tetrafluoroethylene) films by graft copolymerization for adhesion improvement with evaporated copper[J]. Macromolecules, 1999, 32(1): 186-193.

[6] Lin P. H., Bush R. L., Yao Q. Z., et al. Evaluation of platelet deposition and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral artery bypass model[J]. Journal of Surgical Research, 2004, 118(1): 45-52.

[7] Wu R. J., Feng X. D. Surface and Interface of Polymer[M]. 1998, Beijing: Science Press.

[8] Goda T., Konno T., Takai M., et al. Biomimetic phosphorylcholine polymer grafting from polydimethylsiloxane surface using photo-induced polymerization[J]. Biomaterials, 2006, 27(30): 5151-5160.

[9] Lü J. A., Ma J. N., HuangFu P. B., et al. Surface modification with both phosphorylcholine and stearyl groups to adjust hydrophilicity and hydrophobicity[J]. Applied Surface Science, 2008, 225(2): 498-501.

[10] Kang E. T., Zhang Y. Surface modification of fluoropolymer via molecular design[J]. Advanced Materials, 2000, 12(20): 1481-1494.

[11] Laroche G, Mantovani D, Chevallier P et al. Modification of Material Surface Properties Involving Exposing Surface to Plasma Treatment Conditions to Create Reactive Groups and Activating Molecule to Produce Reactive Molecular Species [P]. WO200270032-A, 2002-09-12.

[12] Wang H. L. Hemostasia and Thrombus Testing Technique[M]. 1992, Shanghai: Shanghai Scientific and Technology Press.

[13] Chen J. R. Low Temperature Plasma Chemistry and Application[M]. 2001, Beijing: Science Press.

[14] Watanabe J., Ishihara K. Change in cell adhesion property on cytocompatible interface using phospholipid polymer grafted with poly (D,L-lactic acid) segment for tissue engineering[J]. Science and Technology of Advanced Material, 2003, 4(6): 539-544.

[15] Wu S. Y. Polymer Interface and Adhesion[M]. 1987, Beijing: China Textile Press.