Glycemic variability is a more sensitive assessment of glycemic health as opposed to traditional clinical measurements. It considers all blood glucose concentrations over a given period to better account for glucose oscillations that occur and provides clinicians with insight into how individuals regulate and/or maintain their glycemic health. The advancement of continuous glucose monitoring (CGM) allows for the measurement of free-living glucose concentrations while providing a more reliable assessment of treatment of dysregulated glycemic. CGM coupled with management of lifestyle behavioral factors, such as reduced sedentary behavior and increased physical activity and regular exercise, potentially offers a previously untapped method for promoting improved glycemic health through greater regulation of glucose concentrations. The aim of this review is to critically evaluate the evidence regarding the measurement of glycemic variability and summarize the current understanding of the relationship between glycemic variability, sedentary behavior, physical activity, the influence of a single exercise session or repeated exercise sessions, and exercise training. This review considers information pertaining to the strengths and limitations for measuring glycemic variability and provides insight into future study designs aimed at evaluating the relationship between sedentary behavior and physical activity with, as well as the influence of exercise on, glycemic variability as a primary outcome.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly caused pneumonia and pulmonary fibrosis through upper respiratory tract infection, which resulted in acute respiratory distress syndrome (ARDS) and multiorgan damage of cardiovascular, nervous, digestive, and genitourinary systems. Although the virus test turned negative after the patient recovered, the damage to multiorgan caused by SARS-CoV-2 may irreversible. Therefore, the health status of the recovered patients has gradually become the focus of people's attention. Whether coronavirus disease 2019 (COVID-19) patients can receive exercise rehabilitation training after discharge? and what's the basis? We try to analyze and answer these questions, will provide some ideas about the patients to develop a reasonable and effective exercise rehabilitation program.
In daily functional activities, the body needs the ability to perform two or more tasks at the same time (such as talking while walking). However, the gait disorder of patients with Parkinson's disease is aggravated when performing dual tasks, which seriously affects their quality of life. Therefore, the medical management plan should offer effective exercise training programming to improve Parkinson's disease patients' ability to perform dual tasks. Most traditional exercise intervention methods only focus on the perspective of exercise or cognition, ignoring their interaction, and fail to adequately resolve the dual task obstacles associated with Parkinson's disease. Some scholars put forward the concept of dual-task training and have applied dual-task training to patients with neurological disorders and have achieved good therapeutic effects. Therefore, this article summarizes the research literature concerning dual-task training to improve cognitive impairment and walking function of Parkinson's disease patients, to evaluate and discuss possible mechanisms of action, and provide a basis for adjuvant treatment and rehabilitation of Parkinson's disease patients.
Swimrun was established in Sweden in 2006. In competition athletes alternate between running and swimming multiple times. It has grown from only being hosted in Sweden to now being a global sport. The swimrun race exposes athletes to environments that require a unique set of skills. For example, participants have to negotiate ocean currents and waves. The environmental conditions change between the runs and the swims. Athletes may be exposed to hot temperatures when running in wetsuits (25 °C and hotter) and cold water (colder than 16 °C) when swimming. This sudden change in environmental conditions imposes a poorly defined physiological stress on the participants. Research on the demands of swimrun is scarce. More research is needed to improve athlete safety during events. Also, research is needed to provide insight into enhancing training methods and performance.
Diet-induced obesity has previously been shown to occur with the concomitant rise in the expression of proinflammatory cytokines and increases in collagen deposition. While it has been known that the regenerative process of skeletal muscle is altered in obese mice following an acute muscle injury, we sought to examine differences in the expression of various markers of extracellular matrix remodeling and repair. Our laboratory has previously reported an impaired inflammatory and protein synthetic signaling in these mice that may contribute negatively to the muscle regenerative process. To expand upon this previous investigation, tissues from these animals underwent further analysis to determine the extent of changes to the regenerative response within the extracellular matrix, including transcriptional changes in Collagen I, Collagen III, and Fibronectin. Here, we show that the expression of Collagen III:I is significantly increased at 3-days post-injury in obese injured animals compared to lean injured animals (p = 0.0338), and by 28-days the obese injured animals exhibit a significantly lower Collagen III:I than their lean injured counterparts (p = 0.0035). We demonstrate an impaired response to an acute muscle injury in obese mice when compared with lean counterparts. However, further studies are required to elucidate translational consequences of these changes, as well as to determine any causative mechanisms that may be driving this effect.
This study was to optimize the exercise preconditioning (EP) intensity in protecting from exhaustive exercise-induced cardiac injury (EECI). A total of 98 male Sprague-Dawley rats were divided into 7 groups (n = 14): the control group (C), the exhaustive exercise group (EE) and the EP + EE groups, which include the V10 (53.0%̇O2max), V15 (58.4%̇O2max), V20 (67.0%̇O2max), V26 (74.0%̇O2max) and V30 (80.0%̇O2max) groups. Except the C group, the other groups were subjected to treadmill running. The serum contents of N terminal pro B type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTn-I) were detected by the enzyme-linked immunosorbent assay method, ECG was recorded, heart function was detected by pressure volume catheter and the activities of mitochondrial electron transfer pathway (ET pathway) complexes I, Ⅱ and IV were measured by high-resolution respiration instrument. Compared to the EE group, the EP groups have shown decrease of NT-proBNP and cTn-I, improvement of mitochondrial respiratory function and cardiac function. Compared to other EP groups, the V26 group has shown significant decrease of myocardial enzymes and improvement of mitochondrial function. The correlation analysis showed the EP effect was proportional to EP intensity in the range of 53.0%̇O2max-74.0%̇O2max. High intensity and long duration of exhaustive exercise caused cardiac injury and EP could decrease serum level of NT-proBNP and cTn-I, improve electrical derangement and the left ventricular function, and raise the activities of ET pathway complexes I, Ⅱ and IV. The protection of EP on EECI was improved as the EP intensity was increased from 53.0%̇O2max to 74.0%̇O2max and when EP intensity was 74.0%̇O2max, the effect was the most obvious among all the setting EP groups.
The coronavirus disease 2019 (COVID-19) pandemic led to sudden extreme changes in lifestyle, potentially causing adverse changes in physical activity, sedentary behavior, and dietary habits. The objective of the study was to investigate the effects of COVID-19 quarantine on physical activity, dietary habits, and food insecurity among college students who were impacted by the quarantine periods and campus closures. The findings of the study will provide preliminary evidence on dietary, physical activity, and sedentary behavior changes induced by the pandemic among college students.
Participants (n = 403) completed a cross-sectional self-report online questionnaire, evaluating the physical activity, sedentary behavior, and dietary behaviors before- and during-COVID-19 campus closures (March-May 2020). Sociodemographic and descriptive information was also obtained from each participant. Wilcoxon signed-rank test was used to assess changes in physical activity, sedentary behavior, and dietary habits. McNemar's test was used to compare food insecurity changes. Data were presented as median and interquartile range.
A total of 291 participants who met the inclusion criteria were enrolled in the study (college-aged, 18-24 years). Physical activity decreased at vigorous (2 days/week to 1 day/week, p < 0.001), moderate (4 days/week to 1 day/week, p < 0.001), and light (4 days/week to 2 days/week, p < 0.001) intensity levels, while sedentary behavior increased (4 h/day to 7 h/day, p < 0.001) from pre-to during-COVID-19 quarantine period. Frequencies of meals at home and alcohol consumption increased (Z = −3.911 and Z = −4.022, p < 0.001), while frequency of fruit consumption decreased (Z = −2.116, p < 0.001) from pre-to during-COVID-19 quarantine period. Daily alcohol intake also increased during COVID-19 quarantine period (Z = −4.442, p < 0.001). Lastly, the percentage of individuals reporting food insecurity significantly increased during COVID-19 quarantine (p < 0.001).
College-aged students in quarantine significantly decreased physical activity participation and increased sedentary behavior. Changes in dietary habits were observed, including increased meals at home, alcohol consumption, and decreased fruit consumption. Food insecurity also doubled among college-aged students during quarantine. Public health strategies to attenuate these changes in lifestyle habits should be implemented during a global pandemic.
The purpose of this study was to identify correlates of changes in physical activity (PA) and sedentary behaviour (SB) among university-based young adults in Bangladesh. Data were from a 1-year prospective study with 2 assessment points (baseline n = 573, 20.7 ± 1.35 years, 45% female; retention rate 69%, analytical sample = 395). Participants completed a self-administered written survey on PA, SB, health and lifestyle behaviours, and sociodemographics. Changes in PA were categorised as: negligible (± < 60 min/week), > 60 min/week decrease, or > 60 min/week increase. Changes in SB were categorised as negligible (± < 120 min/week), > 120 min/week decrease, and > 120 min/week increase. Multinomial logistic regression analysis was used to identify the correlates. About quarters (72%) of participants had insufficient PA at both assessment points. Of those who were sufficiently active at Wave 1, 5% became insufficiently active at Wave 2. One quarter of participants (23%) had high SB at Wave 1 and Wave 2. Of those who had low SB at Wave 1, 16% had high SB at Wave 2. Being male [OR = 2.04 (95% CI: 1.06-3.93)], baseline phone time of > 2 h/day [OR = 3.14 (95% CI: 1.04-7.04)] and not participating in organised sports at baseline [OR = 2.56 (95% CI: 1.24-5.29) were associated with a decrease in PA by > 60 min/week. Participants who frequently experienced stress at baseline had higher odds of increasing SB by > 120 min/day [OR = 1.83 (95% CI: 1.04-3.23)]. SB is more variable than PA over 1 year in university-based young adults in Bangladesh. Males, those with high phone time, those not engaging with organised sports, and those with frequent stress may change to a more inactive lifestyle.
Non-steroidal anti-inflammatory drugs’ anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature (Tc) increases during exercise. We utilized a double-blind, randomized, and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose (3-220 mg naproxen pills) and placebo (0 mg naproxen) on Tc and plasma interleukin-6 (IL-6) concentrations during cycling in a hot or ambient environment. Participants (n = 11; 6 male, 5 female; age = 27.8 ± 6.5 years, weight = 79.1 ± 17.9 kg, height = 177 ± 9.5 cm) completed 4 conditions: 1) placebo and ambient (Control); 2) placebo and heat (Heat); 3) naproxen and ambient (Npx); and 4) naproxen and heat (NpxHeat). Dependent measures were taken before, during, and immediately after 90 min of cycling and then 3 h after cycling. Overall, Tc significantly increased pre- (37.1 ± 0.4 °C) to post-cycling (38.2 ± 0.3 °C, F1.7,67.3 = 150.5, p < 0.001) and decreased during rest (37.0 ± 0.3 °C, F2.0,81.5 = 201.6, p < 0.001). Rate of change or maximum Tc were not significantly different between conditions. IL-6 increased pre- (0.54 ± 0.06 pg/ml) to post-exercise (2.46 ± 0.28 pg/ml, p < 0.001) and remained significantly higher than pre-at 3 h post- (1.17 ± 0.14 pg/ml, 95% CI = −1.01 to −0.23, p = 0.001). No significant IL-6 differences occurred between conditions. A 24-h, over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.