Diagnostics of bronchopulmonary diseases through Mahalanobis distance-based absorption spectral analysis of exhaled air

Abstract

Accurate diagnosis of different bronchopulmonary diseases is important in clinical practice. This study involved 20 healthy volunteers and 77 patients with bronchopulmonary diseases, including chronic obstructive pulmonary disease (COPD), bronchial asthma, pulmonary tuberculosis, and community-acquired pneumonia. The absorption spectrum of exhaled air samples was recorded on an intra-cavity photo-acoustic gas analyzer (ILPA-1, Special Technologies, Ltd., Russia) with photo-acoustic detectors and CO₂ laser with a tuning range from 9.2 to 10.8 µm. In conclusion, analysis of the Mahalanobis distance-based absorption spectral profiles of breath air from bronchopulmonary patients and healthy volunteers allows the formulation of a preliminary diagnosis.

Keywords

bronchopulmonary diseases / exhaled air / Mahalanobis distance / laser photo-acoustic spectroscopy / CO₂ laser

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Acknowledgements

The work was carried out with the partial financial support of the Federal Special Purpose Program contract No 14.578.21.0082 (ID RFMEFI57814X0082).

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg