RESEARCH ARTCILE

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

  • Yanli LIU ,
  • Rong LIU ,
  • Cheng ZHEN ,
  • Quanfang GUO ,
  • Liping WU ,
  • Zhaoxi DING ,
  • Yushun BI ,
  • Zhiyu LIU
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  • Department of Anatomy, Shandong University School of Medicine, Jinan 250012, China

Received date: 11 Nov 2008

Accepted date: 26 Nov 2008

Published date: 05 Mar 2009

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injury that was caused by Bacille Calmette Guerin (BCG) and lipopolysaccharide (LPS), a total of 60 mice were adopted, among which, 50 mice were given intraperitoneal injection with BCG and LPS to establish an immunological liver injury model and then were randomly divided into 5 groups (10 mice/group): 4 groups received treatment of FGL orally at the doses of 100 mg/kg (high-dosage), 50 mg/kg (middle-dosage), 25 mg/kg (low-dosage) and bifendate orally at the dose of 80 mg/kg, respectively. One group was treated with distilled water orally. The remaining 10 mice were given distilled water intraperitoneally as the normal control group. The indices of thymus, liver and spleen, and the activities of the alanine aminotransferase (ALT), aspartate aminotransferase (AST) in the serum were detected. Compared to the normal rat, the model group’s thymus index decreased significantly. The liver index and spleen index increased significantly. The activities of serum ALT and AST increased significantly (all P< 0.01). Compared to the model control group, the group treated with FGL in high-dosage, middle-dosage or low-dosage can decrease the activities of ALT and AST and the group treated with FGL in high-dosage and middle-dosage can increase the thymus index significantly (P< 0.01). This experiment established the immunological liver injury model successfully and found that FGL has a remarkably protective effect on this kind of immunological hepatic injury.

Cite this article

Yanli LIU , Rong LIU , Cheng ZHEN , Quanfang GUO , Liping WU , Zhaoxi DING , Yushun BI , Zhiyu LIU . Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury[J]. Frontiers of Medicine, 2009 , 3(1) : 91 -95 . DOI: 10.1007/s11684-009-0011-z

Acknowledgements

This work was supported by the Key Project of the State Commission of Science and Technology of China (029010572).
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