NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis
Received date: 17 Oct 2008
Accepted date: 29 Oct 2008
Published date: 05 Mar 2009
Copyright
Reactive oxygen species (ROS) are small molecule metabolites of oxygen that are prone to participate in redox reactions via their high reactivity. Intracellular ROS could be generated in reduced nicotinamide-adenine dinucleotidephosphate (NADPH) oxidase-dependent and/or NADPH oxidase-independent manners. Physiologically, ROS are involved in many signaling cascades that contribute to normal processes. One classical example is that ROS derived from the NADPH oxidase and released in neurotrophils are able to digest invading bacteria. Excessive ROS, however, contribute to pathogenesis of various human diseases including cancer, aging, dimentia and hypertension. As signaling messengers, ROS are able to oxidize many targets such as DNA, proteins and lipids, which may be linked with tumor growth, invasion or metastasis. The present review summarizes recent advances in our comprehensive understanding of ROS-linked signaling pathways in regulation of tumor growth, invasion and metastasis, and focuses on the role of the NADPH oxidase-derived ROS in cancer pathogenesis.
Key words: free radicals; tumor; phox; cell proliferation; cancer therapy
Gang WANG . NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis[J]. Frontiers of Medicine, 2009 , 3(1) : 1 -7 . DOI: 10.1007/s11684-009-0018-5
1 |
LambethJ D. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol, 2004, 4(3): 181-189
|
2 |
WangG. In: Schwab M, eds. Encyclopedia of Cancer: Reactive oxygen species. 2nd ed. Berlin, Heidelberg, New York: Springer-Verlag. 2008,2559-2562
|
3 |
KanofskyJ R. Singlet oxygen production by biological systems. Chem Biol Interact, 1989, 70(1--2): 1-28
|
4 |
QuinnM T, AmmonsM C, DeLeoF R. The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction. Clin Sci, 2006, 111(1): 1-20
|
5 |
HordijkP L. Regulation of NADPH oxidases: the role of Rac proteins. Circ Res, 2006, 98 (4): 453-463
|
6 |
DoladoI, SwatA, AjenjoN, De VitaG, CuadradoA, NebredaA R. p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell, 2007, 11(2): 191-205
|
7 |
KomatsuD, KatoM, NakayamaJ, MiyagawaS, KamataT. NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene, 2008, 27(34): 4724-4732
|
8 |
NakamuraH, NakamuraK, YodoiJ. Redox regulation of cellular activation. Ann Rev Immunol, 1997, 15: 351-369
|
9 |
ValkoM, RhodesC J, MoncolJ, IzakovicM, MazurM. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact, 2006, 160(1): 1-40
|
10 |
WuW S. The signaling mechanism of ROS in tumor progression. Cancer Metast Rev, 2006, 25(4): 695-705
|
11 |
XiaC, MengQ, LiuL Z, RojanasakulY, WangX R, JiangB H. Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res, 2007, 67(22): 10823-10830
|
12 |
BrarS S, CorbinZ, KennedyT P, HemendingerR, ThorntonL, BommariusB, ArnoldR S, WhortonA R, SturrockA B, HuecksteadtT P, QuinnM T, KrenitskyK, ArdieK G, LambethJ D, HoidalJ R. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol, 2003, 285(2): c353-369
|
13 |
BrarS S, KennedyT P, SturrockA B, HuecksteadtT P, QuinnM T, WhortonA R, HoidalJ R. An NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am J Physiol Cell Physiol, 2002, 282(6): c1212-1224
|
14 |
OhshimaH, TatemichiM. In: Vainio H U, Hietanen E K, eds. Infections, inflammation and cancer: roles of reactive oxygen and nitrogen species. Berlin, Heidelberg, New York: Springer-Verlag. 2003: 211-222
|
15 |
KeyerK, GortA S, ImlayJ A. Superoxide and the production of oxidative DNA damage. J Bacteriol, 1995, 177(23): 6782-6790
|
16 |
MooreR J, OwensD M, StampG, ArnottC, BurkeF, EastN, HoldsworthH, TurnerL, RollinsB, PasparakisM, KolliasG, BalkwillF. Mice deficient in tumor necrosis factor-alpha are resis tant to skin carcinogenesis. Nat Med, 1999, 5(7): 828-831
|
17 |
PikarskyE, PoratR M, SteinI, AbramovitchR, AmitS, KasemS, Gutkovich-PyestE, Urieli-ShovalS, GalunE, Ben-NeriahY. NF-kappa B functions as a tumour promoter in inflammation-associated cancer. Nature, 2004, 431(7007): 461-466
|
18 |
OhshimaH, TazawaH, SyllaB S, SawaT. Prevention of human cancer by modulation of chronic inflammatory processes. Mutat Res, 2005, 591(1--2): 110-122
|
19 |
KimY, LeeY S, ChoeJ, LeeH, KimY M, JeoungD. CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. J Biol Chem, 2008, 283(33): 22513-22528
|
20 |
Ushio-FukaiM, NakamuraY. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett, 2008, 266(1): 37-52
|
21 |
ValkoM, LeibfritzD, MoncolJ, CroninM T, MazurM, TelserJ. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol, 2007, 39(1): 44-84
|
22 |
WarzochaK, RibeiroP, BienvenuJ, RoyP, CharlotC, RigalD, CoiffierB, SallesG. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome. Blood, 1998, 91(10): 3574-3581
|
23 |
NishinoH, TokudaH, SatomiY, MasudaM, OsakaY, YogosawaS, WadaS, MouX Y, TakayasuJ, MurakoshiM, JinnnoK, YanoM. Cancer prevention by antioxidants. Biofactors, 2004, 22(1-4): 57-61
|
24 |
LeeK T, TsaiS M, WangS N, LinS K, WuS H, ChuangS C, WuS H, MaH, TsaiL Y. Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma. Clin Biochem, 2007, 40(15): 1157-1162
|
25 |
DasS, KhanN, MukherjeeS, BagchiD, GurusamyN, SwartzH, DasD K. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Free Radic Biol Med, 2008, 44(1): 82-90
|
26 |
ShankarS, GanapathyS, SrivastavaR K. Green tea polyphenols: biology and therapeutic implications in cancer. Front Biosci, 2007, 12: 4881-4899
|
27 |
TianB, XuZ, SunZ, LinJ, HuaY. Evaluation of the antioxidant effects of carotenoids from Deinococcus radiodurans through targeted mutagenesis, chemiluminescence, and DNA damage analyses. Biochim Biophys Acta, 2007, 1770(6): 902-911
|
28 |
BedardK, KrauseK H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev, 2007, 87(1): 245-313
|
29 |
WangG, AnratherJ, GlassM J, TarsitanoM J, ZhouP, FrysK A, PickelV M, IadecolaC. Nox2, Ca2+ and PKC play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension, 2006, 48 (3): 482-489
|
30 |
WilkinsonB L, LandrethG E. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer’s disease. J Neuroinflamm, 2006, 3: 30
|
31 |
TieuK, IschiropoulosH, PrzedborskiS. Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB Life, 2003, 55(6): 329-335
|
/
〈 | 〉 |