Frontiers of Medicine >

2011 , Vol. 5 >Issue 2: 229 - 234

DOI: https://doi.org/10.1007/s11684-011-0139-5

RESEARCH ARTICLE

Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice

  • Liyun He , 1 ,
  • Tiancai Wen 1 ,
  • Shiyan Yan 1 ,
  • Runjin Li 2 ,
  • Zufa Liu 3 ,
  • Hui Ren 4 ,
  • Jinmin Liu 5 ,
  • Fengshan Zhang 6 ,
  • Jianzhong Wu 7 ,
  • Jian Liu 8
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  • 1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. Inner Mongolia People’s Hospital, Hohhot 010017, China
  • 3. Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China
  • 4. The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China
  • 5. Beijing University of Traditional Chinese Medicine Oriental Hospital, Beijing 100078, China
  • 6. Tongliao Hospital, Tongliao 026000, China
  • 7. China Association Against Epilepsy, Beijing 100044, China
  • 8. Kunming Chinese Medicine Factory Co., Ltd., Kunming 650228, China

Received date: 21 Mar 2011

Accepted date: 18 Apr 2011

Published date: 05 Jun 2011

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 137 patients, we combined Dianxianning with chemical medicine, which is the basic treatment. For the control group with 69 patients, we added placebo. The results showed that 1) Effect on seizure rate: After a three-month treatment, the seizure rate of the treatment group decreased by 37.84% on average, whereas that of the control group decreased by 13.18% on average. Statistically comparing the two groups, there was a significant difference between these groups (P<0.05). 2) Effect on seizure frequency: As time passed, the frequency in each group gradually decreased. After a three-month treatment, there was a significant difference between the two groups (P<0.05). 3) Comparison between the before and after treatment of each group: There was a very significant difference between the two groups (P<0.0001). The results indicated that, as an additive treatment, Dianxianning has a good effect on controlling the epilepsy seizure rate and frequency management. It is more effective than using chemical medicine alone.

Key words： Dianxianning; epilepsy seizure; evaluation

Cite this article

Liyun He , Tiancai Wen , Shiyan Yan , Runjin Li , Zufa Liu , Hui Ren , Jinmin Liu , Fengshan Zhang , Jianzhong Wu , Jian Liu . Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice[J]. Frontiers of Medicine, 2011 , 5(2) : 229 -234 . DOI: 10.1007/s11684-011-0139-5

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