REVIEW

Therapeutic potential of stem cell in liver regeneration

  • Jinzheng LI ,
  • Min LI ,
  • Bolin NIU ,
  • Jianping GONG
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  • Chongqing Key Laboratory of Hepatobiliary Surgery and Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China

Received date: 02 Dec 2010

Accepted date: 23 Dec 2010

Published date: 05 Mar 2011

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

Liver transplantation is the only life-saving procedure for patients with end-stage liver disease. However, its potential benefits are hampered by many disadvantages, such as the relative shortage of donors, operative risks, and high costs. These issues have prompted the search for new alternative therapies for irreversible liver disease. Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation, is a promising alternative approach. Several studies have demonstrated that transplantation of hepatic stem/progenitor cells or hepatocyte-like cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver and improved survival rates in experimental models of liver disease. However, a registered clinical application based on stem cell technology will take at least an additional 5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratoma formation. This review summarizes the general understanding of the therapeutic potentials of stem cells in liver disease, including the sources, mechanisms, and delivery methods of hepatic stem cells in liver regeneration, and discusses some challenges for their therapeutic application.

Cite this article

Jinzheng LI , Min LI , Bolin NIU , Jianping GONG . Therapeutic potential of stem cell in liver regeneration[J]. Frontiers of Medicine, 2011 , 5(1) : 26 -32 . DOI: 10.1007/s11684-011-0107-0

Acknowledgment

This study was supported by the National Natural Science Foundation of China (Grant NO.81070374, NO.3080112).
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