REVIEW

High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

  • Lian ZHANG 1 ,
  • Zhi-Biao WANG , 1,2,3
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  • 1. Clinical Center for Tumor Therapy of 2nd Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China
  • 2. State Key Laboratory, Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing 400037, China
  • 3. National Engineering and Research Center for Ultrasound Medicine, Chongqing 401121, China

Received date: 30 Apr 2010

Accepted date: 12 May 2010

Published date: 05 Sep 2010

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg

Abstract

High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.

Cite this article

Lian ZHANG , Zhi-Biao WANG . High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience[J]. Frontiers of Medicine, 2010 , 4(3) : 294 -302 . DOI: 10.1007/s11684-010-0092-8

Acknowledgements

We are grateful to Wendy (Wenyi) ZHANG for helping us edit and revise this review.
1
LynnJ G, ZwemerR L, ChickA J, MillerA E. A new method for the generation and use of focused ultrasound in experiment biology. J Gen Physiol, 1942, 26(2): 179–193

DOI

2
WangZ B, WuF, WangZ L, ZhangZ, ZouJ Z, LiuC, LiuY G, ChengG, DuY H, HeZ C, GuM L, WangZ G, FengR. Targeted damage effects of high intensity focused ultrasound (HIFU) on liver tissues of Guizhou Province miniswine. Ultrason Sonochem, 1997, 4(2): 181–182

DOI

3
HynynenK, PomeroyO, SmithD N, HuberP E, McDannoldN J, KettenbachJ, BaumJ, SingerS, JoleszF A. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study. Radiology, 2001, 219(1): 176–185

4
WuF, WangZ B, ZhuH, ChenW Z, ZouJ Z, BaiJ, LiK Q, JinC B, XieF L, SuH B. Feasibility of US-guided high-intensity focused ultrasound treatment in patients with advanced pancreatic cancer: initial experience. Radiology, 2005, 236(3): 1034–1040

DOI

5
WuF, WangZ B, ChenW Z, WangW, GuiY, ZhangM, ZhengG, ZhouY, XuG, LiM, ZhangC, YeH, FengR. Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview. Ultrason Sonochem, 2004, 11(3-4): 149–154

DOI

6
ZhangL, ChenW Z, LiuY J, HuX, ZhouK, ChenL, PengS, ZhuH, ZouH L, BaiJ, WangZ B. Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus. Eur J Radiol, 2010, 73(2): 396–403

DOI

7
FinnH A, SimonM A. Limb-salvage surgery in the treatment of osteosarcoma in skeletally immature individuals. Clin Orthop Relat Res, 1991, 262(262): 108–118

8
RimnerA, BrennanM F, ZhangZ, SingerS, AlektiarK M. Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh. Cancer, 2009, 115(1): 149–157

DOI

9
MittermayerF, KreplerP, DominkusM, SchwameisE, SlugaM, HeinzlH, KotzR. Long-term followup of uncemented tumor endoprostheses for the lower extremity. Clin Orthop Relat Res, 2001, 388(388): 167–177

DOI

10
MrozT E, JoyceM J, SteinmetzM P, LiebermanI H, WangJ C. Musculoskeletal allograft risks and recalls in the United States. J Am Acad Orthop Surg, 2008, 16(10): 559–565

11
EaganM J, McAllisterD R. Biology of allograft incorporation. Clin Sports Med, 2009, 28(2): 203–214, vii

DOI

12
WuF, ChenW Z, BaiJ, ZouJ Z, WangZ L, ZhuH, WangZ B. Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. Ultrasound Med Biol, 2001, 27(8): 1099–1106

DOI

13
ChenW, WangZ, WuF, ZhuH, ZouJ, BaiJ, LiK, XieF. High intensity focused ultrasound in the treatment of primary malignant bone tumor. Zhonghua Zhong Liu Za Zhi, 2002, 24(6): 612–615 (in Chinese)

14
ChenW, ZhouK. High-intensity focused ultrasound ablation: a new strategy to manage primary bone tumors. Curr Opin Orthop, 2006, 16(6): 494–500

DOI

15
ChenW, WangZ, WuF, ZhuH, ZouJ, BaiJ, LiK, XieF. High intensity focused ultrasound in the treatment of primary malignant bone tumor. Zhonghua Zhong Liu Za Zhi, 2002, 24(6): 612–615 (in Chinese)

16
WuF, WangZ B, ChenW Z, ZouJ Z, BaiJ, ZhuH, LiK Q, XieF L, JinC B, SuH B, GaoG W. Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience. Ultrasound Med Biol, 2004, 30(2): 245–260

DOI

17
ChenW, ZhuH, ZhangL, LiK, SuH, JinC, ZhouK, BaiJ, WuF, WangZ. Primary bone malignancy: Effective treatment with high-intensity focused ultrasound ablation. Radiology, 2010, 255(3): 968–978

DOI

18
WenzhiC, RheeS, WeiW, BaiL, ZhouJ, HuiZ, WangZ, WuF, LiK, ZhouK. Comparison of clinical outcome of osteosarcomas after treatment of surgery and HIFU. In: Proceedings of the 6th International Symposium on Therapeutic Ultrasound, 2006

19
WuF, WangZ, ChenW. Pathological study of extracorporeally ablated hepatocellular carcinoma with high-intensity focused ultrasound. Zhonghua Zhong Liu Za Zhi, 2001, 23(3): 237–239 (in Chinese)

20
WuF, WangZ B, ChenW Z, ZouJ Z, BaiJ, ZhuH, LiK Q, JinC B, XieF L, SuH B. Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization. Radiology, 2005, 235(2): 659–667

DOI

21
LiY Y, ShaW H, ZhouY J, NieY Q. Short and long term efficacy of high intensity focused ultrasound therapy for advanced hepatocellular carcinoma. J Gastroenterol Hepatol, 2007, 22(12): 2148–2154

DOI

22
IllingR O, KennedyJ E, WuF, ter HaarG R, ProtheroeA S, FriendP J, GleesonF V, CranstonD W, PhillipsR R, MiddletonM R. The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. Br J Cancer, 2005, 93(8): 890–895

DOI

23
ZhangL, ZhuH, JinC, ZhouK, LiK, SuH, ChenW, BaiJ, WangZ. High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins. Eur Radiol, 2009, 19(2): 437–445

DOI

24
OrsiF, ZhangL, ArnoneP, BonomoG, VignaP D, MonfardiniL, ZhouK, ChenW Z, WangZ B, VeronesiU. High intensity focused ultrasound (HIFU) ablation: Effective and safe therapy for solid tumors at difficult locations. AJR Am J Roentgenol, (in press)

25
WuF, WangZ B, ZhuH, ChenW Z, ZouJ Z, BaiJ, LiK Q, JinC B, XieF L, SuH B. Feasibility of US-guided high-intensity focused ultrasound treatment in patients with advanced pancreatic cancer: initial experience. Radiology, 2005, 236(3): 1034–1040

DOI

26
WangX, SunJ. High-intensity focused ultrasound in patients with late-stage pancreatic carcinoma. Chin Med J (Engl), 2002, 115(9): 1332–1335

27
WuF, WangZ B, CaoY D, ChenW Z, BaiJ, ZouJ Z, ZhuH. A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer, 2003, 89(12): 2227–2233

DOI

28
WuF, WangZ B, CaoY D, ChenW Z, ZouJ Z, BaiJ, ZhuH, LiK Q, JinC B, XieF L, SuH B, GaoG W. Changes in biologic characteristics of breast cancer treated with high-intensity focused ultrasound. Ultrasound Med Biol, 2003, 29(10): 1487–1492

DOI

29
WuF, WangZ B, CaoY D, XuZ L, ZhouQ, ZhuH, ChenW Z. Heat fixation of cancer cells ablated with high-intensity-focused ultrasound in patients with breast cancer. Am J Surg, 2006, 192(2): 179–184

DOI

30
WuF, WangZ B, ZhuH, ChenW Z, ZouJ Z, BaiJ, LiK Q, JinC B, XieF L, SuH B. Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer. Breast Cancer Res Treat, 2005, 92(1): 51–60

DOI

31
WuF, WangZ B, ChenW Z, BaiJ, ZhuH, QiaoT Y. Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy. J Urol, 2003, 170(6 Pt 1): 2237–2240

DOI

32
ButtramV C Jr, ReiterR C. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril, 1981, 36(4): 433–445

33
NishiyamaS, SaitoM, SatoK, KurishitaM, ItasakaT, ShiodaK. High recurrence rate of uterine fibroids on transvaginal ultrasound after abdominal myomectomy in Japanese women. Gynecol Obstet Invest, 2006, 61(3): 155–159

DOI

34
MäkinenJ, JohanssonJ, TomásC, TomásE, HeinonenP K, LaatikainenT, KaukoM, HeikkinenA M, SjöbergJ. Morbidity of 10 110 hysterectomies by type of approach. Hum Reprod, 2001, 16(7): 1473–1478

DOI

35
WangW, LiuW Y, ZhouJ M, XuJ M, GaiL H, HuangC J. High-intensity focused ultrasound treatment for symptomatic uterine fibroids: Preliminary results. Zhonghua Chao Sheng Ying Xiang Xue Za Zhi, 2002, 11(3): 161–163 (in Chinese)

36
HeH, LuL, ZhouY, NieY. Clinical study of curing uterine leiomyoma with high intensity focused ultrasound. Zhongguo Xian Dai Yi Xue Za Zhi, 2004, 14(19): 9 (in Chinese)

37
WangY, WangW, WangL, WangJ, TangJ. Ultrasound-guided high-intensity focused ultrasound treatment for abdominal wall endometriosis: Preliminary results. Eur J Radiol, 2010<month>Jan</month><day>28</day>. doi:10.1016/j.ejrad.2009.12.034

DOI

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