Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective

Abstract

The pursuit of healthy aging has long rendered aging and senescence captivating. Age-related ailments, such as cardiovascular diseases, diabetes, and neurodegenerative disorders, pose significant threats to individuals. Recent studies have shed light on the intricate mechanisms encompassing genetics, epigenetics, transcriptomics, and metabolomics in the processes of senescence and aging, as well as the establishment of age-related pathologies. Amidst these underlying mechanisms governing aging and related pathology metabolism assumes a pivotal role that holds promise for intervention and therapeutics. The advancements in metabolomics techniques and analysis methods have significantly propelled the study of senescence and aging, particularly with the aid of multiscale metabolomics which has facilitated the discovery of metabolic markers and therapeutic potentials. This review provides an overview of senescence and aging, emphasizing the crucial role metabolism plays in the aging process as well as age-related diseases.

Keywords

metabolism / aging / senescence / age-related diseases / metabolomics

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Acknowledgements

This study was supported by National Key R&D Program of China (Nos. 2021YFA0804900 and 2020YFA0112203), the National Natural Science Foundation of China (Nos. 32225020, 92049304 and 32121002 to W.X., Nos. 32322033, 21974130 and 91849116 to H.Z.), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB39050000), Key Research Program of Frontier Science, CAS (No. ZDBS-LY-SM002), CAS Interdisciplinary Innovation Team (No. JCTD-2018-20), the Youth Innovation Promotion Association CAS, the Fundamental Research Funds for the Central Universities, USTC Research Funds of the Double First-Class Initiative (No. YD9100002001 to W.X. and No. YD9100002005 to H.Z.), CAS Project for Young Scientists in Basic Research (No. YSBR-013), University Synergy Innovation Program of Anhui Province (No. GXXT-2022-033).

Compliance with ethics guidelines

Conflicts of interest Ziyi Wang, Hongying Zhu, and Wei Xiong declare no conflicts of interest.

This article is a review article and does not involve a research protocol requiring approval by a relevant institutional review board or ethics committee.

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