Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice

Zhen He , Yufei Wang , Siyu Zhang , Zhenwang Zhao , Xiaobo Hu

Front. Med. ›› 2025, Vol. 19 ›› Issue (1) : 181 -183.

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Front. Med. ›› 2025, Vol. 19 ›› Issue (1) : 181 -183. DOI: 10.1007/s11684-024-1112-4
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Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice

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Zhen He, Yufei Wang, Siyu Zhang, Zhenwang Zhao, Xiaobo Hu. Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice. Front. Med., 2025, 19(1): 181-183 DOI:10.1007/s11684-024-1112-4

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References

[1]

Botto C, Rucli M, Tekinsoy MD, Pulman J, Sahel JA, Dalkara D. Early and late stage gene therapy interventions for inherited retinal degenerations. Prog Retin Eye Res 2022; 86: 100975

[2]

Ayash J, Woods RL, Akula JD, Rajabi F, Alwattar BK, Altschwager P, Fulton AB. Characteristics of eyes with CRB1-associated EOSRD/LCA: age-related changes. Am J Ophthalmol 2024; 263: 168–178

[3]

Ehrenberg M, Pierce EA, Cox GF, Fulton AB. CRB1: one gene, many phenotypes. Semin Ophthalmol 2013; 28(5–6): 397–405

[4]

Peng S, Li JJ, Song W, Li Y, Zeng L, Liang Q, Wen X, Shang H, Liu K, Peng P, Xue W, Zou B, Yang L, Liang J, Zhang Z, Guo S, Chen T, Li W, Jin M, Xing XB, Wan P, Liu C, Lin H, Wei H, Lee RWJ, Zhang F, Wei L. CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut. Cell 2024; 187(6): 1387–1401.e13

[5]

den Hollander AI, Ghiani M, de Kok YJ, Wijnholds J, Ballabio A, Cremers FP, Broccoli V. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev 2002; 110(1–2): 203–207

[6]

Huang CH, Yang CM, Yang CH, Hou YC, Chen TC. Leber’s congenital amaurosis: current concepts of genotype-phenotype correlations. Genes (Basel) 2021; 12(8): 1261

[7]

Trapani I, Auricchio A. Has retinal gene therapy come of age? From bench to bedside and back to bench. Hum Mol Genet 2019; 28(R1): R108–R118

[8]

Darrow JJ. Luxturna: FDA documents reveal the value of a costly gene therapy. Drug Discov Today 2019; 24(4): 949–954

[9]

Liu Y, Tai J, Yu C, Xu D, Xiao D, Pang J. Unlocking therapeutic potential: dual gene therapy for ameliorating the disease phenotypes in a mouse model of RPE65 Leber congenital amaurosis. Front Med (Lausanne) 2024; 10: 1291795

[10]

Napolitano P, Filippelli M, Davinelli S, Bartollino S, dell’Omo R, Costagliola C. Influence of gut microbiota on eye diseases: an overview. Ann Med 2021; 53(1): 750–761

[11]

Deng Y, Ge X, Li Y, Zou B, Wen X, Chen W, Lu L, Zhang M, Zhang X, Li C, Zhao C, Lin X, Zhang X, Huang X, Li X, Jin M, Peng GH, Wang D, Wang X, Lai W, Liang J, Li JJ, Liang Q, Yang L, Zhang Q, Li Y, Lu P, Hu X, Li X, Deng X, Liu Y, Zou Y, Guo S, Chen T, Qin Y, Yang F, Miao L, Chen W, Chan CC, Lin H, Liu Y, Lee RWJ, Wei L. Identification of an intraocular microbiota. Cell Discov 2021; 7(1): 13

[12]

Labetoulle M, Baudouin C, Benitez Del Castillo JM, Rolando M, Rescigno M, Messmer EM, Aragona P. How gut microbiota may impact ocular surface homeostasis and related disorders. Prog Retin Eye Res 2024; 100: 101250

[13]

Jin Y, Li S, Jiang Z, Sun L, Huang L, Zhang T, Liu X, Ding X. Genotype-phenotype of CRB1-associated early-onset retinal dystrophy: novel insights on retinal architecture and therapeutic window for clinical trials. Invest Ophthalmol Vis Sci 2024; 65(3): 11

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