Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice

Zhen He, Yufei Wang, Siyu Zhang, Zhenwang Zhao, Xiaobo Hu

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Front. Med. ›› DOI: 10.1007/s11684-024-1112-4
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Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice

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Zhen He, Yufei Wang, Siyu Zhang, Zhenwang Zhao, Xiaobo Hu. Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice. Front. Med., https://doi.org/10.1007/s11684-024-1112-4

References

[1]
Botto C , Rucli M , Tekinsoy MD , Pulman J , Sahel JA , Dalkara D . Early and late stage gene therapy interventions for inherited retinal degenerations. Prog Retin Eye Res 2022; 86: 100975
CrossRef Google scholar
[2]
Ayash J , Woods RL , Akula JD , Rajabi F , Alwattar BK , Altschwager P , Fulton AB . Characteristics of eyes with CRB1-associated EOSRD/LCA: age-related changes. Am J Ophthalmol 2024; 263: 168–178
CrossRef Google scholar
[3]
Ehrenberg M , Pierce EA , Cox GF , Fulton AB . CRB1: one gene, many phenotypes. Semin Ophthalmol 2013; 28(5–6): 397–405
CrossRef Google scholar
[4]
Peng S , Li JJ , Song W , Li Y , Zeng L , Liang Q , Wen X , Shang H , Liu K , Peng P , Xue W , Zou B , Yang L , Liang J , Zhang Z , Guo S , Chen T , Li W , Jin M , Xing XB , Wan P , Liu C , Lin H , Wei H , Lee RWJ , Zhang F , Wei L . CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut. Cell 2024; 187(6): 1387–1401.e13
CrossRef Google scholar
[5]
den Hollander AI , Ghiani M , de Kok YJ , Wijnholds J , Ballabio A , Cremers FP , Broccoli V . Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev 2002; 110(1–2): 203–207
CrossRef Google scholar
[6]
Huang CH , Yang CM , Yang CH , Hou YC , Chen TC . Leber’s congenital amaurosis: current concepts of genotype-phenotype correlations. Genes (Basel) 2021; 12(8): 1261
CrossRef Google scholar
[7]
Trapani I , Auricchio A . Has retinal gene therapy come of age? From bench to bedside and back to bench. Hum Mol Genet 2019; 28(R1): R108–R118
CrossRef Google scholar
[8]
Darrow JJ . Luxturna: FDA documents reveal the value of a costly gene therapy. Drug Discov Today 2019; 24(4): 949–954
CrossRef Google scholar
[9]
Liu Y , Tai J , Yu C , Xu D , Xiao D , Pang J . Unlocking therapeutic potential: dual gene therapy for ameliorating the disease phenotypes in a mouse model of RPE65 Leber congenital amaurosis. Front Med (Lausanne) 2024; 10: 1291795
CrossRef Google scholar
[10]
Napolitano P , Filippelli M , Davinelli S , Bartollino S , dell’Omo R , Costagliola C . Influence of gut microbiota on eye diseases: an overview. Ann Med 2021; 53(1): 750–761
CrossRef Google scholar
[11]
Deng Y , Ge X , Li Y , Zou B , Wen X , Chen W , Lu L , Zhang M , Zhang X , Li C , Zhao C , Lin X , Zhang X , Huang X , Li X , Jin M , Peng GH , Wang D , Wang X , Lai W , Liang J , Li JJ , Liang Q , Yang L , Zhang Q , Li Y , Lu P , Hu X , Li X , Deng X , Liu Y , Zou Y , Guo S , Chen T , Qin Y , Yang F , Miao L , Chen W , Chan CC , Lin H , Liu Y , Lee RWJ , Wei L . Identification of an intraocular microbiota. Cell Discov 2021; 7(1): 13
CrossRef Google scholar
[12]
Labetoulle M , Baudouin C , Benitez Del Castillo JM , Rolando M , Rescigno M , Messmer EM , Aragona P . How gut microbiota may impact ocular surface homeostasis and related disorders. Prog Retin Eye Res 2024; 100: 101250
CrossRef Google scholar
[13]
Jin Y , Li S , Jiang Z , Sun L , Huang L , Zhang T , Liu X , Ding X . Genotype-phenotype of CRB1-associated early-onset retinal dystrophy: novel insights on retinal architecture and therapeutic window for clinical trials. Invest Ophthalmol Vis Sci 2024; 65(3): 11
CrossRef Google scholar

Acknowledgements

This work was supported by the grants from the National Natural Science Foundation of China (No. 82300522), Hubei Provincial Natural Science Foundation of China (No. 2023AFB043), Undergraduate Research and Innovation Project of University of South China (Nos. X202310555117 and S202410555041).

Compliance with ethics guidelines

Conflicts of interest Zhen He, Yufei Wang, Siyu Zhang, Zhenwang Zhao, and Xiaobo Hu declare no competing financial interests.
This manuscript is a comment and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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