Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke

Abstract

The coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the past three years. An increasing number of studies have identified a complex relationship between COVID-19 and stroke, although active measures are being implemented to prevent disease transmission. Severe COVID-19 may be associated with an increased risk of stroke and increase the rates of disability and mortality, posing a serious challenge to acute stroke diagnosis, treatment, and care. This review aims to provide an update on the influence of COVID-19 itself or vaccines on stroke, including arterial stroke (ischemic stroke and hemorrhagic stroke) and venous stroke (cerebral venous thrombosis). Additionally, the neurovascular mechanisms involved in SARS-CoV-2 infection and the clinical characteristics of stroke in the COVID-19 setting are presented. Evidence on vaccinations, potential therapeutic approaches, and effective strategies for stroke management has been highlighted.

Keywords

SARS-CoV-2 / ischemic stroke / stroke / hemorrhagic stroke / cerebral venous thrombosis / vaccination

Lu Liu et al.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (No. 82027802), Pharmaceutical Collaboration Project of the Beijing Science and Technology Commission (No. Z181100001918026), and Talents Gathering Project of Xuanwu Hospital, Capital Medical University.

Parts of the Fig.1 and Fig.2 were drawn by using pictures from Servier Medical Art, licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).

Electronic Supplementary Material

Supplementary material is available in the online version of this article at https://doi.org/10.1007/s11684-023-1041-7 and is accessible for authorized users.

Compliance with ethics guidelines

Conflicts of Interest Lu Liu, Chenxia Zhou, Huimin Jiang, Huimin Wei, Yifan Zhou, Chen Zhou, and Xunming Ji declare that they have no conflict of interest.

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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