Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Abstract

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of intercellular communication and tissue repair. One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy, such as immune rejection or stem cells differentiating into unwanted cell types. However, further research is necessary to optimize exosome therapy, not only in the areas of exosome isolation, characterization, and engineering, but also in determining the optimal dose, timing, administration, and frequency of exosome therapy. Thus, optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer, ischemia, or inflammation. This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

Keywords

exosomes / stem cells / therapeutic impact / skin / wound healing

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82060245 and 82260254); Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Contract Nos. R21 AI152832 and R03 AI165170 (PI: Yuanyuan Zhang).

Compliance with ethics guidelines

Conflicts of interest Tianjing Sun, Mo Li, Qi Liu, Anyong Yu, Kun Chen, Jianxing Ma, Sean Murphy, Patrick Michael McNutt, and Yuanyuan Zhang declare that they have no conflict of interest.

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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