Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

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Acknowledgements

This work was sponsored by the National Natural Science Foundation of China (Nos. 81974391, 82072806, and 82173265); the National Natural Science Foundation of China for Youths (No. 8200100057); Program of Shanghai Academic/Technology Research Leader (No. 19XD1405100); Clinical Research Plan of SHDC (No. SHDC2020CR4025); Shanghai “Rising Stars of Medical Talent” Youth Development Program: Youth Medical Talents – Specialist Program (Xiuwu Pan); Shanghai Municipal Commission of Health and Family Planning (No. 20204Y0042); Technology Project of Jiading District Health System (No. 2019-QN-03); Natural Science Foundation of Shanghai (No. 20ZR1470500); Hospital Funded Clinical Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (No. 21XHDB06).

Compliance with ethics guidelines

Conflicts of interest Wenjin Chen, Xiuwu Pan, Wang Zhou, Da Xu, Jiaxin Chen, Keqin Dong, Weijie Chen, Brian Rini, and Xingang Cui declare no conflict of interest.

All authors have confirmed the publication. All primary data presented in this study are available from the corresponding author upon reasonable request and the sequencing data have been uploaded to the Genome Sequence Archive of Human in the BIG Data Center, Chinese Academy of Sciences under accession codes HRA002590 for that are publicly accessible at the website of NGDC-GSA for Human.The study was approved by the ethical review boards of the Third Affiliated Hospital of the Second Military Medical University (EHBHKY2020-K-026) and Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (XHEC-C-2021-145-1) and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all patients for being included in the study.

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