Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Abstract

Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL) due to their reliable efficacy, manageable safety, high accessibility, and convenience for use. Still, no guidelines or consensus focusing on oral drug therapies for BCL is available. To provide a reference of oral agent-based treatment for mature BCL, a panel of experts from the Lymphocyte Disease Group, Chinese Society of Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China, combined with the latest authoritative guidelines in the world and current research reports. This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients. With the deepening of research and the development of standardized clinical applications, oral medications will bring better treatment to BCL patients, enabling more patients to benefit from them.

Keywords

B-cell lymphoma / oral drug / targeted therapy / immunotherapy / COVID-19 pandemic

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Acknowledgements

We wish to acknowledge the members of the Lymphocyte Disease Group, Chinese Society of Hematology, Chinese Medical Association for their important contributions to all stages of this consensus.

Compliance with ethics guidelines

Suning Chen, Weili Zhao, Jianyong Li, Depei Wu, and Lymphoid disease Group, Chinese Society of Hematology, Chinese Medical Association declare that they have no competing interests. This manuscript is a consensus and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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