Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle cell lymphoma

Abstract

Mantle cell lymphoma (MCL) is a distinct histological type of B-cell lymphoma with a poor prognosis. Several agents, such as proteasome inhibitors, immunomodulatory drugs, and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory (r/r) MCL but often have short-term responses. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma. However, long-term safety and tolerability associated with CAR T-cell therapy are not defined well, especially in MCL. In this report, we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy. CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient. This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL, who are generally elderly and have comorbid conditions.

Keywords

anti-CD19 chimeric antigen receptor T cells / mantle cell lymphoma / relapsed or refractory / long-term follow-up

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Acknowledgements

This study was supported by grants from the Shanghai Municipal Hospital New Frontier Technology Joint Research Project (No. SHDC12015108), the National Natural Science Foundation of China (Nos. 81830004, 31301118, and 81272325) and the Fundamental Research Funds for the Central Universities (No. 22120170004).

Compliance with ethics guidelines

Ping Li, Ningxin Dong, Yu Zeng, Jie Liu, Xiaocheng Tang, Junbang Wang, Wenjun Zhang, Shiguang Ye, Lili Zhou, Alex Hongsheng Chang, and Aibin Liang declare that they have no conflict of interest. Informed consent was obtained from all patients upon enrollment in the CAR T-cell study. The study was conducted in accordance with the Declaration of Helsinki. The study protocol was approved by the Ethics Committee of Tongji Hospital of Tongji University School of Medicine.

Electronic Supplementary Material

Supplementary material is available in the online version of this article at https://doi.org/10.1007/s11684-020-0740-6 and is accessible for authorized users.

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