Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu , Xun Tian , Chun Gao , Ping Wu , Liming Wang , Bei Feng , Xiaomin Li , Hui Wang , Ding Ma , Zheng Hu
Front. Med. ›› 2018, Vol. 12 ›› Issue (5) : 497 -508.
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
genome-editing tools / tumorigenic virus / delivery method / off-target effect / virus-related carcinoma
Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature
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