Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Abstract

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D≥31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, P <0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, P = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, P <0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.

Keywords

idiopathic central precocious puberty / threshold effects / vitamin D status

References

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Acknowledgements

We would like to express our gratitude and respect to the children and their parents who have agreed to participate in the research. This study was supported by grants from the 12th Five-Year Plan National Key Technology R&D Program (No. 2012BAI09B04) and the Program for Changjiang Scholars and Innovative Research Team in University (No. PCSIRT1131).

Compliance with ethics guidelines

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, and Xiaoping Luo have declared that they have no conflict of interest. All procedure followed were in accordance with the ethical standards of the responsible committee on human experiment (ethics committee of Huazhong University of Science and Technology) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

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