Caveolin proteins: a molecular insight into disease

Abstract

Caveolae are a kind of specific cystic structures of lipid rafts in the cytoplasmic membrane and are rich in cholesterol and sphingolipids. In recent years, many researchers have found that both caveolins and caveolae play a role in the development of various human diseases, including coronary heart disease, hypertension, and nervous system disorders. The specific mechanisms by which caveolins induce diseases have been a topic of interest. However, a number of detailed molecular mechanisms remain poorly understood. This article focuses on the relationship between caveolin proteins and human diseases and reviews the molecular mechanisms of caveolins in disease networks.

Keywords

caveolin / caveolae / microRNA / disease / signaling pathway / heart / tumor

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81470490 and 81670238).

Compliance with ethics guidelines

Hongli Yin, Tianyi Liu, Ying Zhang, and Baofeng Yang declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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2016 Higher Education Press and Springer-Verlag Berlin Heidelberg