Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Abstract

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progression. Tumor progression is a complex process regulated by a gene network. The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecular network and its cooperative genes by further exploring the biological functions of this gene. We used TCGA data sets and GeneCards database to screen MTA1-related genes. GO and KEGG pathway analyses were conducted with DAVID and gene network analysis via STRING and Cytoscape. Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such as Wnt/Notch/nucleotide excision repair pathways. The findings also suggested that MTA1 demonstrates the closest relationship in a coregulation process with the key molecules AKT1, EP300, CREBBP, SMARCA4, RHOA, and CAD. These results lead MTA1 exploration to an in-depth investigation in different directions, such as Wnt, Notch, and DNA repair.

Keywords

metastasis-associated gene 1 / colon cancer / bioinformatics

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Acknowledgements

This work was financially supported by grants from the National Natural Science Foundation of China (Nos. 81372159, 81372158, and 81572842).

Compliance with ethics guidelines

Chunxiao Li, Haijuan Wang, Feng Lin, Hui Li, Tao Wen, Haili Qian, and Qimin Zhan declare that they have no conflict of interest. This article does not involve any direct research with human or animal subjects.

RIGHTS & PERMISSIONS

2016 Higher Education Press and Springer-Verlag Berlin Heidelberg