Small cell carcinoma of the urinary bladder without gross hematuria: a case report
Wanqiu Huang, Yang Luan, Lu Jin, Tao Wang, Ruibao Chen, Zheng Liu, Zhiqiang Chen, Ruzhu Lan
Small cell carcinoma of the urinary bladder without gross hematuria: a case report
Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.
carcinoma / small cell / urinary bladder neoplasms / diagnosis
[1] |
Cheng L, Pan CX, Yang XJ, Lopez-Beltran A, MacLennan GT, Lin H, Kuzel TM, Papavero V, Tretiakova M, Nigro K, Koch MO, Eble JN. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer2004; 101(5): 957–962
CrossRef
Pubmed
Google scholar
|
[2] |
Trias I, Algaba F, Condom E, Español I, Seguí J, Orsola I, Villavicencio H, García Del Muro X. Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases. Eur Urol2001; 39(1): 85–90
CrossRef
Pubmed
Google scholar
|
[3] |
Cramer SF, Aikawa M, Cebelin M. Neurosecretory granules in small cell invasive carcinoma of the urinary bladder. Cancer1981; 47(4): 724–730
CrossRef
Pubmed
Google scholar
|
[4] |
Blomjous CE, Vos W, De Voogt HJ, Van der Valk P, Meijer CJ. Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer1989; 64(6): 1347–1357
CrossRef
Pubmed
Google scholar
|
[5] |
Choong NW, Quevedo JF, Kaur JS. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer2005; 103(6): 1172–1178
CrossRef
Pubmed
Google scholar
|
[6] |
Hou CP, Lin YH, Chen CL, Chang PL, Tsui KH. Clinical outcome of primary small cell carcinoma of the urinary bladder. Onco Targets Ther2013; 6: 1179–1185
Pubmed
|
[7] |
Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS. Small cell carcinoma of the bladder. BJU Int2004; 94(1): 12–17
CrossRef
Pubmed
Google scholar
|
[8] |
Ismaili N, Elkarak F, Heudel PE, Flechon A, Droz JP. Small cell cancer of the bladder: The Leon-Berard cancer centre experience. Indian J Urol2008; 24(4): 494–497
CrossRef
Pubmed
Google scholar
|
[9] |
Siefker-Radtke AO, Dinney CP, Abrahams NA, Moran C, Shen Y, Pisters LL, Grossman HB, Swanson DA, Millikan RE. Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J Urol2004; 172(2): 481–484
CrossRef
Pubmed
Google scholar
|
[10] |
Lohrisch C, Murray N, Pickles T, Sullivan L. Small cell carcinoma of the bladder: long term outcome with integrated chemoradiation. Cancer1999; 86(11): 2346–2352
CrossRef
Pubmed
Google scholar
|
[11] |
Reyes CV, Soneru I. Small cell carcinoma of the urinary bladder with hypercalcemia. Cancer1985; 56(10): 2530–2533
CrossRef
Pubmed
Google scholar
|
[12] |
Gon S, Majumdar B, Dey RK, Mitra SK. Pure primary small cell carcinoma of urinary bladder: a rare diagnostic entity. Urol Ann2013; 5(3): 209–211
CrossRef
Pubmed
Google scholar
|
[13] |
Epstein JI, Amin MB, Reuter VE. Bladder biopsy interpretation. MA: Lippincott Williams and Wilkins2004: 126–128
|
[14] |
Jones TD, Kernek KM, Yang XJ, Lopez-Beltran A, MacLennan GT, Eble JN, Lin H, Pan CX, Tretiakova M, Baldridge LA, Cheng L. Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum Pathol2005; 36(7): 718–723
CrossRef
Pubmed
Google scholar
|
[15] |
Soriano P, Navarro S, Gil M, Llombart-Bosch A. Small-cell carcinoma of the urinary bladder. A clinico-pathological study of ten cases. Virchows Arch2004; 445(3): 292–297
CrossRef
Pubmed
Google scholar
|
[16] |
Karpman E, Goldberg Z, Saffarian A, Gandour-Edwards R, Ellison LM, deVere White RW. Analysis of treatment for small cell cancer of the bladder and report of three cases. Urology2004; 64(3): 494–498
CrossRef
Pubmed
Google scholar
|
[17] |
Iczkowski KA, Shanks JH, Bostwick DG. Loss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma. Histopathology1998; 32(4): 322–327
CrossRef
Pubmed
Google scholar
|
[18] |
Alijo Serrano F, Sánchez-Mora N, Angel Arranz J, Hernández C, Alvarez-Fernández E. Large cell and small cell neuroendocrine bladder carcinoma: immunohistochemical and outcome study in a single institution. Am J Clin Pathol2007; 128(5): 733–739
CrossRef
Google scholar
|
[19] |
Church DN, Bahl A. Clinical review—<?Pub Caret?>small cell carcinoma of the bladder. Cancer Treat Rev2006; 32(8): 588–593
CrossRef
Pubmed
Google scholar
|
[20] |
Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol2003; 44(6): 672–681
CrossRef
Pubmed
Google scholar
|
[21] |
Abrahams NA, Moran C, Reyes AO, Siefker-Radtke A, Ayala AG. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology2005; 46(1): 57–63
CrossRef
Pubmed
Google scholar
|
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