Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang, Yang Luan, Lu Jin, Tao Wang, Ruibao Chen, Zheng Liu, Zhiqiang Chen, Ruzhu Lan

PDF(535 KB)
PDF(535 KB)
Front. Med. ›› 2015, Vol. 9 ›› Issue (3) : 384-387. DOI: 10.1007/s11684-015-0405-z
CASE REPORT
CASE REPORT

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Author information +
History +

Abstract

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.

Keywords

carcinoma / small cell / urinary bladder neoplasms / diagnosis

Cite this article

Download citation ▾
Wanqiu Huang, Yang Luan, Lu Jin, Tao Wang, Ruibao Chen, Zheng Liu, Zhiqiang Chen, Ruzhu Lan. Small cell carcinoma of the urinary bladder without gross hematuria: a case report. Front. Med., 2015, 9(3): 384‒387 https://doi.org/10.1007/s11684-015-0405-z

References

[1]
Cheng L, Pan CX, Yang XJ, Lopez-Beltran A, MacLennan GT, Lin H, Kuzel TM, Papavero V, Tretiakova M, Nigro K, Koch MO, Eble JN. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer2004; 101(5): 957–962
CrossRef Pubmed Google scholar
[2]
Trias I, Algaba F, Condom E, Español I, Seguí J, Orsola I, Villavicencio H, García Del Muro X. Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases. Eur Urol2001; 39(1): 85–90
CrossRef Pubmed Google scholar
[3]
Cramer SF, Aikawa M, Cebelin M. Neurosecretory granules in small cell invasive carcinoma of the urinary bladder. Cancer1981; 47(4): 724–730
CrossRef Pubmed Google scholar
[4]
Blomjous CE, Vos W, De Voogt HJ, Van der Valk P, Meijer CJ. Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer1989; 64(6): 1347–1357
CrossRef Pubmed Google scholar
[5]
Choong NW, Quevedo JF, Kaur JS. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer2005; 103(6): 1172–1178
CrossRef Pubmed Google scholar
[6]
Hou CP, Lin YH, Chen CL, Chang PL, Tsui KH. Clinical outcome of primary small cell carcinoma of the urinary bladder. Onco Targets Ther2013; 6: 1179–1185
Pubmed
[7]
Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS. Small cell carcinoma of the bladder. BJU Int2004; 94(1): 12–17
CrossRef Pubmed Google scholar
[8]
Ismaili N, Elkarak F, Heudel PE, Flechon A, Droz JP. Small cell cancer of the bladder: The Leon-Berard cancer centre experience. Indian J Urol2008; 24(4): 494–497
CrossRef Pubmed Google scholar
[9]
Siefker-Radtke AO, Dinney CP, Abrahams NA, Moran C, Shen Y, Pisters LL, Grossman HB, Swanson DA, Millikan RE. Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J Urol2004; 172(2): 481–484
CrossRef Pubmed Google scholar
[10]
Lohrisch C, Murray N, Pickles T, Sullivan L. Small cell carcinoma of the bladder: long term outcome with integrated chemoradiation. Cancer1999; 86(11): 2346–2352
CrossRef Pubmed Google scholar
[11]
Reyes CV, Soneru I. Small cell carcinoma of the urinary bladder with hypercalcemia. Cancer1985; 56(10): 2530–2533
CrossRef Pubmed Google scholar
[12]
Gon S, Majumdar B, Dey RK, Mitra SK. Pure primary small cell carcinoma of urinary bladder: a rare diagnostic entity. Urol Ann2013; 5(3): 209–211
CrossRef Pubmed Google scholar
[13]
Epstein JI, Amin MB, Reuter VE. Bladder biopsy interpretation. MA: Lippincott Williams and Wilkins2004: 126–128
[14]
Jones TD, Kernek KM, Yang XJ, Lopez-Beltran A, MacLennan GT, Eble JN, Lin H, Pan CX, Tretiakova M, Baldridge LA, Cheng L. Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum Pathol2005; 36(7): 718–723
CrossRef Pubmed Google scholar
[15]
Soriano P, Navarro S, Gil M, Llombart-Bosch A. Small-cell carcinoma of the urinary bladder. A clinico-pathological study of ten cases. Virchows Arch2004; 445(3): 292–297
CrossRef Pubmed Google scholar
[16]
Karpman E, Goldberg Z, Saffarian A, Gandour-Edwards R, Ellison LM, deVere White RW. Analysis of treatment for small cell cancer of the bladder and report of three cases. Urology2004; 64(3): 494–498
CrossRef Pubmed Google scholar
[17]
Iczkowski KA, Shanks JH, Bostwick DG. Loss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma. Histopathology1998; 32(4): 322–327
CrossRef Pubmed Google scholar
[18]
Alijo Serrano F, Sánchez-Mora N, Angel Arranz J, Hernández C, Alvarez-Fernández E. Large cell and small cell neuroendocrine bladder carcinoma: immunohistochemical and outcome study in a single institution. Am J Clin Pathol2007; 128(5): 733–739
CrossRef Google scholar
[19]
Church DN, Bahl A. Clinical review—<?Pub Caret?>small cell carcinoma of the bladder. Cancer Treat Rev2006; 32(8): 588–593
CrossRef Pubmed Google scholar
[20]
Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol2003; 44(6): 672–681
CrossRef Pubmed Google scholar
[21]
Abrahams NA, Moran C, Reyes AO, Siefker-Radtke A, Ayala AG. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology2005; 46(1): 57–63
CrossRef Pubmed Google scholar
Compliance with ethics guidelines
Wanqiu Huang, Yang Luan, Lu Jin, Tao Wang, Ruibao Chen, Zheng Liu, Zhiqiang Chen, and Ruzhu Lan declare that no conflicts of interest exist. This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Informed consent was obtained from the patient. Additional informed consent was obtained from all patients whose identifying information was included in this article.

RIGHTS & PERMISSIONS

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
AI Summary AI Mindmap
PDF(535 KB)

Accesses

Citations

Detail

Sections
Recommended

/